Literature DB >> 12176395

Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants.

Agnes W Boots1, Guido R M M Haenen, Gertjan J M den Hartog, Aalt Bast.   

Abstract

Catechol-containing antioxidants are able to protect against lipid peroxidation by nonenzymatic scavenging of free radicals with their catechol moiety. During their antioxidant activity, catechol oxidation products such as semiquinone radicals and quinones are formed. These oxidation products of 4-methylcatechol inactivate the GSH-dependent protection against lipid peroxidation and the calcium sequestration in liver microsomes. This effect is probably due to arylation by oxidation products of 4-methylcatechol of free thiol groups of the enzymes responsible for the GSH-dependent protection and calcium sequestration, i.e. the free radical reductase and calcium ATPase. It is concluded that a catechol-containing antioxidant might shift radical damage from lipid peroxidation to sulfhydryl arylation.

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Year:  2002        PMID： 12176395     DOI： 10.1016/s1388-1981(02)00247-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


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