| Literature DB >> 12175934 |
Paramita Ghosh1, Subhendu Ghosh, Sudipto Das.
Abstract
We have studied the functioning of rat liver Connexin 32 (C x 32) at the single channel level in presence of ATP. It was observed that ATP regulates the functioning of the channel by running down the junctional conductance. A non-specific exogenous protein phosphatase (alkaline phosphatase) reversed the rundown of junctional activity to its normal functioning state. Autoradiograhic studies demonstrate autophosphorylation of rat liver C x 32. These findings indicate a self-regulatory mechanism of the channel.Entities:
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Year: 2002 PMID： 12175934 DOI： 10.1016/s0005-2736(02)00504-7
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002