| Literature DB >> 12175605 |
G L Mariottini1, E Sottofattori, M Mazzei, L Robbiano, A Carli.
Abstract
The activity of Pelagia noctiluca venom was never assessed on cultured cells; therefore, we have evaluated on V79 cells the cytotoxicity, genotoxicity and ATP depletion induced after treatment. Venom did not cause alteration on cell DNA, but showed remarkable cytotoxic properties. With the highest nematocyst concentration (150,000 nematocyst/ml) 74 and 39% cells survived after 1 and 3 h, respectively, when evaluated by Trypan blue. Treated cells showed increased ATP levels during the same time. Preliminary HPLC analyses have showed the occurrence of a protein containing peak. Copright 2002 Elsevier Science Ltd.Entities:
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Year: 2002 PMID： 12175605 DOI： 10.1016/s0041-0101(01)00262-8
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033