Literature DB >> 12175533

CYP1A1, GSTM1, and GSTT1 polymorphisms and breast cancer risk in Brazilian women.

Lídia da Fonte de Amorim1, Ana Rossini, Gulnar Mendonça, Priscila Lotsch, Tatiana de Almeida Simão, Cláudia de Moura Gallo, Luis Pinto.   

Abstract

The frequency of CYP1A1 (CYP1A1*2A), GSTM1, and GSTT1 polymorphisms, as well as the main risk factors associated with breast cancer were studied in Brazilian women, with malignant breast cancer (n=128), or age-matched controls (n=256). Only a family history of breast cancer presented a significant risk (OR=3.00, CI=1.27-7.06). Among non-whites, the CYP1A1*2A allele was underrepresented among patients. Statistical analysis indicated that this polymorphism may decrease the risk of breast cancer among these individuals, particularly after adjusting for the risk presented by selected risk factors (OR=0.30, 95% CI=0.12-0.76).

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Year:  2002        PMID： 12175533     DOI： 10.1016/s0304-3835(02)00058-7

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


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