| Literature DB >> 12175529 |
Yoshiaki Atsuta1, Naoko Aoki, Keisuke Sato, Kensuke Oikawa, Hitoshi Nochi, Naoyuki Miyokawa, Satoshi Hirata, Shoji Kimura, Tadahiro Sasajima, Makoto Katagiri.
Abstract
The immunological screening of breast cancer was performed with IgG autoantibodies by the serological analysis of recombinant cDNA expression library methods to explore novel tumor associated antigens. We have focused on a small zinc finger protein metallopanstimulin-1 (MPS-1). MPS-1 mRNA was ubiquitously expressed in normal human tissues except the brain and the placenta. In Western blot analysis, MPS-1 was easily detected strongly in actively proliferating cells and three breast cancer cell lines. In the tissue the protein of MPS-1 in cancer cells was more abundant than that of surrounding normal cells. Screening of tissue specimens by immunohistochemistry revealed 50.4% positive for MPS-1 in 125 cancer patients. These data suggest that MPS-1 could be applicable to the immunotherapy of breast cancer.Entities:
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Year: 2002 PMID： 12175529 DOI： 10.1016/s0304-3835(02)00068-x
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679