OBJECTIVE: The aim of this study was to find if a complete synovial fluid aspiration before injection of intra-articular high molecular weight hyaluronan influences the treatment result for knees with rheumatoid arthritis (RA), including joint effusion and the prognostic factors related to clinical effect. METHODS: The arthritic knees including effusion were randomized to arthrocentesis or no arthrocentesis before the hyaluronan (1.9-2.5 x 10(6)) was injected into knee joints five times every week. All patients were followed up for 6 months. RESULTS:One hundred eighteen RA patients (80 knees in the arthrocentesis group, 81 knees in the no-arthrocentesis group) were included. The proportion of no relapses in the arthrocentesis group was higher than that in the no-arthrocentesis group. In the arthrocentesis group, regression analysis showed that duration of knee arthritis (<5 months), CRP (<4 mg/dl), and Larsen grade (<grade II) were the significant predictors. CONCLUSIONS: Arthrocentesis is effective in reducing the risk for arthritis relapse by intra-articular hyaluronan injection to rheumatoid knees with joint effusion. Predicting responders are duration of knee arthritis, CRP, and radiological scores.
RCT Entities:
OBJECTIVE: The aim of this study was to find if a complete synovial fluid aspiration before injection of intra-articular high molecular weight hyaluronan influences the treatment result for knees with rheumatoid arthritis (RA), including joint effusion and the prognostic factors related to clinical effect. METHODS: The arthritic knees including effusion were randomized to arthrocentesis or no arthrocentesis before the hyaluronan (1.9-2.5 x 10(6)) was injected into knee joints five times every week. All patients were followed up for 6 months. RESULTS: One hundred eighteen RApatients (80 knees in the arthrocentesis group, 81 knees in the no-arthrocentesis group) were included. The proportion of no relapses in the arthrocentesis group was higher than that in the no-arthrocentesis group. In the arthrocentesis group, regression analysis showed that duration of knee arthritis (<5 months), CRP (<4 mg/dl), and Larsen grade (<grade II) were the significant predictors. CONCLUSIONS: Arthrocentesis is effective in reducing the risk for arthritis relapse by intra-articularhyaluronan injection to rheumatoid knees with joint effusion. Predicting responders are duration of knee arthritis, CRP, and radiological scores.
Authors: Tej B Bhavsar; Wilmer L Sibbitt; Philip A Band; Romy J Cabacungan; Timothy S Moore; Luis C Salayandia; Roderick A Fields; Scarlett K Kettwich; Luis P Roldan; N Suzanne Emil; Monthida Fangtham; Arthur D Bankhurst Journal: Clin Rheumatol Date: 2017-09-14 Impact factor: 2.980
Authors: Colbert E Chavez-Chiang; Wilmer L Sibbitt; Philip A Band; Natalia R Chavez-Chiang; Suzanne L DeLea; Arthur D Bankhurst Journal: Sports Med Arthrosc Rehabil Ther Technol Date: 2011-03-30
Authors: Andreas Roth; Jürgen Mollenhauer; Andreas Wagner; Reneè Fuhrmann; Albrecht Straub; Rudolf A Venbrocks; Peter Petrow; Rolf Bräuer; Harald Schubert; Jörg Ozegowski; Gundela Peschel; Peter J Müller; Raimund W Kinne Journal: Arthritis Res Ther Date: 2005-03-31 Impact factor: 5.156