Literature DB >> 12171558

Hydroxamic acids as pharmacological agents.

E M F Muri1, M J Nieto, R D Sindelar, J S Williamson.   

Abstract

A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A(4) hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.

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Year:  2002        PMID： 12171558     DOI： 10.2174/0929867023369402

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  23 in total

1.  Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

Authors:  Jennifer A Jacobsen; Jessica L Fullagar; Melissa T Miller; Seth M Cohen
Journal:  J Med Chem       Date:  2010-12-28       Impact factor: 7.446

2.  A new approach to cyclic hydroxamic acids: Intramolecular cyclization of N-benzyloxy carbamates with carbon nucleophiles.

Authors:  Yuan Liu; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  Tetrahedron       Date:  2011-03-25       Impact factor: 2.457

3.  Metalloprotein-inhibitor binding: human carbonic anhydrase II as a model for probing metal-ligand interactions in a metalloprotein active site.

Authors:  David P Martin; Zachary S Hann; Seth M Cohen
Journal:  Inorg Chem       Date:  2013-05-24       Impact factor: 5.165

4.  A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin.

Authors:  Amanda L McClerren; Stephanie Endsley; Jason L Bowman; Niels H Andersen; Ziqiang Guan; Johannes Rudolph; Christian R H Raetz
Journal:  Biochemistry       Date:  2005-12-20       Impact factor: 3.162

5.  Reductive Cyclizations of Nitroarenes to Hydroxamic Acids by Visible Light Photoredox Catalysis.

Authors:  Megan A Cismesia; Michael A Ischay; Tehshik P Yoon
Journal:  Synthesis (Stuttg)       Date:  2013-10-01       Impact factor: 3.157

6.  Design and conformational analysis of peptoids containing N-hydroxy amides reveals a unique sheet-like secondary structure.

Authors:  J Aaron Crapster; Joseph R Stringer; Ilia A Guzei; Helen E Blackwell
Journal:  Biopolymers       Date:  2011       Impact factor: 2.505

7.  Peptide deformylase inhibitors as potent antimycobacterial agents.

Authors:  Jeanette W P Teo; Pamela Thayalan; David Beer; Amelia S L Yap; Mahesh Nanjundappa; Xinyi Ngew; Jeyaraj Duraiswamy; Sarah Liung; Veronique Dartois; Mark Schreiber; Samiul Hasan; Michael Cynamon; Neil S Ryder; Xia Yang; Beat Weidmann; Kathryn Bracken; Thomas Dick; Kakoli Mukherjee
Journal:  Antimicrob Agents Chemother       Date:  2006-09-11       Impact factor: 5.191

8.  Biotransformation of Acetamide to Acetohydroxamic Acid at Bench Scale Using Acyl Transferase Activity of Amidase of Geobacillus pallidus BTP-5x MTCC 9225.

Authors:  Monica Sharma; Nitya Nand Sharma; Tek Chand Bhalla
Journal:  Indian J Microbiol       Date:  2011-08-11       Impact factor: 2.461

Review 9.  Carboxylic acid (bio)isosteres in drug design.

Authors:  Carlo Ballatore; Donna M Huryn; Amos B Smith
Journal:  ChemMedChem       Date:  2013-01-29       Impact factor: 3.466

10.  Reactions of N-benzyloxycarbamate derivatives with stabilized carbon nucleophiles: a new synthetic approach to polyhydroxamic acids and other hydroxamate-containing mixed ligand systems.

Authors:  Yuan Liu; Hollie K Jacobs; Aravamudan S Gopalan
Journal:  J Org Chem       Date:  2009-01-16       Impact factor: 4.354
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