Literature DB >> 12171548

Acridine derivatives as chemotherapeutic agents.

William A Denny1.   

Abstract

Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial and antiprotozoal agents. Some work in these areas continues, but recent research has focused mainly on their use as anticancer drugs, because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase enzymes.

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Year:  2002        PMID： 12171548     DOI： 10.2174/0929867023369277

Source DB:  PubMed          Journal:  Curr Med Chem        ISSN： 0929-8673            Impact factor:   4.530


  28 in total

1.  Unusual intercalation of acridin-9-ylthiourea into the 5'-GA/TC DNA base step from the minor groove: implications for the covalent DNA adduct profile of a novel platinum-intercalator conjugate.

Authors:  Hemanta Baruah; Ulrich Bierbach
Journal:  Nucleic Acids Res       Date:  2003-07-15       Impact factor: 16.971

2.  Synthesis, characterization and cytotoxicity studies of palladium(II)-proflavine complexes.

Authors:  Tatyana V Polyanskaya; Irene Kazhdan; D Michelle Motley; Judith A Walmsley
Journal:  J Inorg Biochem       Date:  2010-07-23       Impact factor: 4.155

3.  Synthesis and evaluation of antiproliferative activity of substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides.

Authors:  Somayeh Motavallizadeh; Asal Fallah-Tafti; Saeedeh Maleki; Amir Nasrolahi Shirazi; Mahboobeh Pordeli; Maliheh Safavi; Sussan Kabudanian Ardestani; Shaaban Asd; Rakesh Tiwari; Donghoon Oh; Abbas Shafiee; Alireza Foroumadi; Keykavous Parang; Tahmineh Akbarzadeh
Journal:  Tetrahedron Lett       Date:  2014-01-08       Impact factor: 2.415

4.  Enhanced antiproliferative activity of the new anticancer candidate LPSF/AC04 in cyclodextrin inclusion complexes encapsulated into liposomes.

Authors:  Elisângela A M Mendonça; Mariane C B Lira; Marcelo M Rabello; Isabella M F Cavalcanti; Suely L Galdino; Ivan R Pitta; Maria do Carmo A Lima; Maira G R Pitta; Marcelo Z Hernandes; Nereide S Santos-Magalhães
Journal:  AAPS PharmSciTech       Date:  2012-10-02       Impact factor: 3.246

5.  Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum.

Authors:  Marc O Anderson; John Sherrill; Peter B Madrid; Ally P Liou; Jennifer L Weisman; Joseph L DeRisi; R Kiplin Guy
Journal:  Bioorg Med Chem       Date:  2005-10-10       Impact factor: 3.641

6.  Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer.

Authors:  Etchison Ryan; A Jacobson Blake; A Benoit; M Ferguson David; A Kratzke Robert
Journal:  Invest New Drugs       Date:  2012-07-22       Impact factor: 3.850

7.  Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships.

Authors:  Maris A Cinelli; Brenda Cordero; Thomas S Dexheimer; Yves Pommier; Mark Cushman
Journal:  Bioorg Med Chem       Date:  2009-09-06       Impact factor: 3.641

8.  "One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition.

Authors:  David Monchaud; Anton Granzhan; Nicolas Saettel; Aurore Guédin; Jean-Louis Mergny; Marie-Paule Teulade-Fichou
Journal:  J Nucleic Acids       Date:  2010-05-24

9.  Interactions of sulfur-containing acridine ligands with DNA by ESI-MS.

Authors:  Suncerae I Smith; Frank S Guziec; Lynn Guziec; Jennifer S Brodbelt
Journal:  Analyst       Date:  2009-08-25       Impact factor: 4.616

10.  Synthesis of a Fluorescent Acridone using a Grignard Addition, Oxidation, and Nucleophilic Aromatic Substitution Reaction Sequence.

Authors:  Samuel Goodrich; Miloni Patel; Zachary R Woydziak
Journal:  J Chem Educ       Date:  2015-04-30       Impact factor: 2.979
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