A facile synthesis of novel types of cyclodextrin derivatives by insertion of an aromatic dicarbonyl spacer into a permethylated alpha-cyclodextrin skeleton.

Novel types of cyclodextrin derivatives are easily synthesized by the insertion of an aromatic dicarbonyl spacer into the skeleton of permethylated alpha-cyclodextrin, and the isophthaloyl-inserted one shows almost the same complexing ability toward p-nitrophenol as permethylated beta-cyclodextrin.