M Fishelson1, D Geiger. 1. Computer Science Department, Technion, Haifa 32000, Israel. fmaayan@cs.technion.ac.il
Abstract
MOTIVATION: Genetic linkage analysis is a useful statistical tool for mapping disease genes and for associating functionality of genes with their location on the chromosome. There is a need for a program that computes multipoint likelihood on general pedigrees with many markers that also deals with two-locus disease models. RESULTS: In this paper we present algorithms for performing exact multipoint likelihood calculations on general pedigrees with a large number of highly polymorphic markers, taking into account a variety of disease models. We have implemented these algorithms in a new computer program called SUPERLINK which outperforms leading linkage software with regards to functionality, speed, memory requirements and extensibility.
MOTIVATION: Genetic linkage analysis is a useful statistical tool for mapping disease genes and for associating functionality of genes with their location on the chromosome. There is a need for a program that computes multipoint likelihood on general pedigrees with many markers that also deals with two-locus disease models. RESULTS: In this paper we present algorithms for performing exact multipoint likelihood calculations on general pedigrees with a large number of highly polymorphic markers, taking into account a variety of disease models. We have implemented these algorithms in a new computer program called SUPERLINK which outperforms leading linkage software with regards to functionality, speed, memory requirements and extensibility.
Authors: Asli Sirmaci; Seyra Erbek; Justin Price; Mingqian Huang; Duygu Duman; F Başak Cengiz; Güney Bademci; Suna Tokgöz-Yilmaz; Burcu Hişmi; Hilal Ozdağ; Banu Oztürk; Sevsen Kulaksizoğlu; Erkan Yildirim; Haris Kokotas; Maria Grigoriadou; Michael B Petersen; Hashem Shahin; Moien Kanaan; Mary-Claire King; Zheng-Yi Chen; Susan H Blanton; Xue Z Liu; Stephan Zuchner; Nejat Akar; Mustafa Tekin Journal: Am J Hum Genet Date: 2010-05-06 Impact factor: 11.025
Authors: James S Kehler; Victor A David; Alejandro A Schäffer; Kristina Bajema; Eduardo Eizirik; David K Ryugo; Steven S Hannah; Stephen J O'Brien; Marilyn Menotti-Raymond Journal: J Hered Date: 2007-09-01 Impact factor: 2.645