| Literature DB >> 12169298 |
Karyn M Maclennan1, Cynthia L Darlington, Paul F Smith.
Abstract
Ginkgo biloba extracts such as EGb-761 have been suggested to have a multitude of beneficial effects on CNS function, from enhancing cognitive function in dementia to facilitating recovery from acute forms of neural damage such as hypoxia/ischemia. Ginkgolide B, one of the major components of EGb-761, is a potent platelet-activating factor (PAF) receptor antagonist, which is also regarded as having neuroprotective effects in the CNS. The aim of this review is to summarise and to critically evaluate the current evidence on the CNS effects of EGb-761 and ginkgolide B, with particular emphasis on the data relating to their neuroprotective effects.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12169298 DOI： 10.1016/s0301-0082(02)00015-1
Source DB: PubMed Journal: Prog Neurobiol ISSN： 0301-0082 Impact factor: 11.685