Literature DB >> 12169238

Genetic basis for the origin of cardiac arrhythmias: implications for therapy.

Mackenzi Mbai1, Sridharan Rajamani, Brian P Delisle, Blake D Anson, Corey Anderson, Jonathan C Makielski, Craig T January.   

Abstract

The recognition of the role that genetic abnormalities play in the generation of cardiac arrhythmias and sudden cardiac death has evolved enormously over the past decade. One result is new insight into underlying physiologic and pathophysiologic mechanisms. New therapies based on this evolving insight are being developed. This review summarizes recent discoveries with a focus on the genetic basis of cardiac arrhythmias and their implications for new therapies.

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Year:  2002        PMID： 12169238     DOI： 10.1007/s11886-002-0041-5

Source DB:  PubMed          Journal:  Curr Cardiol Rep        ISSN： 1523-3782            Impact factor:   2.931


  47 in total

1.  Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes.

Authors:  H B Nuss; E Marbán; D C Johns
Journal:  J Clin Invest       Date:  1999-03       Impact factor: 14.808

2.  Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel.

Authors:  M Furutani; M C Trudeau; N Hagiwara; A Seki; Q Gong; Z Zhou; S Imamura; H Nagashima; H Kasanuki; A Takao; K Momma; C T January; G A Robertson; R Matsuoka
Journal:  Circulation       Date:  1999-05-04       Impact factor: 29.690

Review 3.  Inherited long QT syndromes: a paradigm for understanding arrhythmogenesis.

Authors:  D M Roden; P M Spooner
Journal:  J Cardiovasc Electrophysiol       Date:  1999-12

4.  KCNE1 mutations cause jervell and Lange-Nielsen syndrome.

Authors:  E Schulze-Bahr; Q Wang; H Wedekind; W Haverkamp; Q Chen; Y Sun; C Rubie; M Hördt; J A Towbin; M Borggrefe; G Assmann; X Qu; J C Somberg; G Breithardt; C Oberti; H Funke
Journal:  Nat Genet       Date:  1997-11       Impact factor: 38.330

5.  The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.

Authors:  Eckhard Ficker; Carlos A Obejero-Paz; Shuxia Zhao; Arthur M Brown
Journal:  J Biol Chem       Date:  2001-12-10       Impact factor: 5.157

6.  A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome.

Authors:  J Akai; N Makita; H Sakurada; N Shirai; K Ueda; A Kitabatake; K Nakazawa; A Kimura; M Hiraoka
Journal:  FEBS Lett       Date:  2000-08-11       Impact factor: 4.124

7.  Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation.

Authors:  Michel Haïssaguerre; Dipen C Shah; Pierre Jaïs; Morio Shoda; Josef Kautzner; Thomas Arentz; Dietrich Kalushe; Alan Kadish; Mike Griffith; Fiorenzo Gaïta; Teiichi Yamane; Stephane Garrigue; Meleze Hocini; Jacques Clémenty
Journal:  Lancet       Date:  2002-02-23       Impact factor: 79.321

8.  A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine.

Authors:  Carmen R Valdivia; Michael J Ackerman; David J Tester; Tomoyuki Wada; Jorge McCormack; Bin Ye; Jonathan C Makielski
Journal:  Cardiovasc Res       Date:  2002-08-01       Impact factor: 10.787

9.  Evaluation of QT interval duration and dispersion and proposed clinical criteria in diagnosis of long QT syndrome in patients with a genetically uniform type of LQT1.

Authors:  H Swan; K Saarinen; K Kontula; L Toivonen; M Viitasalo
Journal:  J Am Coll Cardiol       Date:  1998-08       Impact factor: 24.094

10.  Pharmacological rescue of human K(+) channel long-QT2 mutations: human ether-a-go-go-related gene rescue without block.

Authors:  Sridharan Rajamani; Corey L Anderson; Blake D Anson; Craig T January
Journal:  Circulation       Date:  2002-06-18       Impact factor: 29.690
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