BACKGROUND: Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis, which is associated with tumor progression or metastasis. PATIENTS AND METHODS: Immunohistochemical analysis was performed in 109 patients with tongue squamous cell carcinoma. Cox's proportional hazards regression analysis was used to identify the multivariate predictive value of the prognostic factors. RESULTS: High VEGF expression was found in 69 patients (63%) and low VEGF expression in 40 patients (37%). VEGF overexpression correlated with Ki-67 and p53 overexpressions (p=0.0034 and 0.0065, respectively). High VEGF expression was significantly associated with advanced stage (stage III and IV)(p=0.048). The 5-year relapse-free survival (RFS) rate of patients with high VEGF expression (20%) was significantly lower than that of patients with low VEGF expression (76%) (p<0.0001). Multivariate analysis revealed that VEGF expression and stage grouping were independent predictors for RFS (p<0.0001 and 0.04, respectively). CONCLUSION: VEGF expression plays an important role in tumorprogression.
BACKGROUND:Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis, which is associated with tumor progression or metastasis. PATIENTS AND METHODS: Immunohistochemical analysis was performed in 109 patients with tongue squamous cell carcinoma. Cox's proportional hazards regression analysis was used to identify the multivariate predictive value of the prognostic factors. RESULTS: High VEGF expression was found in 69 patients (63%) and low VEGF expression in 40 patients (37%). VEGF overexpression correlated with Ki-67 and p53 overexpressions (p=0.0034 and 0.0065, respectively). High VEGF expression was significantly associated with advanced stage (stage III and IV)(p=0.048). The 5-year relapse-free survival (RFS) rate of patients with high VEGF expression (20%) was significantly lower than that of patients with low VEGF expression (76%) (p<0.0001). Multivariate analysis revealed that VEGF expression and stage grouping were independent predictors for RFS (p<0.0001 and 0.04, respectively). CONCLUSION:VEGF expression plays an important role in tumorprogression.
Authors: Jennifer E Bradburn; Ping Pei; Laura A Kresty; James C Lang; Allan J Yates; Adam P McCormick; Susan R Mallery Journal: Anticancer Res Date: 2007 Nov-Dec Impact factor: 2.480
Authors: Daisuke Sano; David R Fooshee; Mei Zhao; Genevieve A Andrews; Mitchell J Frederick; Chad Galer; Zvonimir L Milas; Phuong Khanh H Morrow; Jeffrey N Myers Journal: Head Neck Date: 2011-03 Impact factor: 3.147
Authors: R Hitt; A Jimeno; M Rodríguez-Pinilla; J L Rodríguez-Peralto; J M Millán; A López-Martín; A Brandariz; C Peña; H Cortés-Funes Journal: Br J Cancer Date: 2004-12-13 Impact factor: 7.640