BACKGROUND: Investigation of transcription regulators in carcinoma can contribute greatly to clarifying the biological character of the carcinoma. In this study, we examined the expression of ets-1 and ets-2, prominent transcription regulators belonging to the ets family, in various colonic tissues. MATERIALS AND METHODS: We investigated the expression of ets-1 and ets-2 in normal colon, hyperplastic polyps, adenomas, carcinoma-in-adenoma and colonic adenocarcinomas by means of immunohistochemistry. RESULTS: Expression of ets-1 and ets-2 was not observed in normal colon and hyperplastic polyp. The ets-1 labeling index significantly increased with the successive events of colonic carcinogenesis. A similar tendency was observed for ets-2 expression in colonic neoplasms. In adenocarcinoma, ets-1 and ets-2 expression was directly linked to lymph node metastasis. CONCLUSION: These results suggest that ets-1 and ets-2 may act as transcription regulators of the genes related to colonic carcinogenesis and the progression of colonic adenocarcinoma.
BACKGROUND: Investigation of transcription regulators in carcinoma can contribute greatly to clarifying the biological character of the carcinoma. In this study, we examined the expression of ets-1 and ets-2, prominent transcription regulators belonging to the ets family, in various colonic tissues. MATERIALS AND METHODS: We investigated the expression of ets-1 and ets-2 in normal colon, hyperplastic polyps, adenomas, carcinoma-in-adenoma and colonic adenocarcinomas by means of immunohistochemistry. RESULTS: Expression of ets-1 and ets-2 was not observed in normal colon and hyperplastic polyp. The ets-1 labeling index significantly increased with the successive events of colonic carcinogenesis. A similar tendency was observed for ets-2 expression in colonic neoplasms. In adenocarcinoma, ets-1 and ets-2 expression was directly linked to lymph node metastasis. CONCLUSION: These results suggest that ets-1 and ets-2 may act as transcription regulators of the genes related to colonic carcinogenesis and the progression of colonic adenocarcinoma.
Authors: Liu Enyu; Niu Zhengchuan; Wang Jiayong; Liang Benjia; Sun Qi; Qin Ruixi; Peng Cheng; Abdul Qadir Khan; Song Wei; Niu Jun Journal: Tumour Biol Date: 2015-05-17
Authors: Omar Moussa; David P Turner; Ron J Feldman; Victor I Sementchenko; Brent D McCarragher; Mohamed M Desouki; Mostafa Fraig; Dennis K Watson Journal: J Cell Biochem Date: 2009-12-15 Impact factor: 4.429