OBJECTIVE: the aim of our study was determination of the relationship between angiogenesis and clinical as well as histological features in laryngeal cancer. METHODS: we used two different methods of estimation of the amount of microvessels in the series of 55 cases, e.g. classical count of endothelial cells group (h-MVD) and digital image measurement of the vessel density (VD). RESULTS: neither h-MVD nor VD correlated significantly with clinical features of the tumour. The results of VD examination correlated significantly with the existence of nodal metastases (P=0.02). The relationship between h-MVD and N status was on the statistical borderline (P=0.07). Multivariate analysis of Cox's proportional hazards model revealed that only N status correlated significantly with patients' survival. CONCLUSION: our results indicate that measurements of angiogenesis in laryngeal cancer may be of some value in predicting N status in laryngeal cancer patients. This issue should be confirmed in prospective studies.
OBJECTIVE: the aim of our study was determination of the relationship between angiogenesis and clinical as well as histological features in laryngeal cancer. METHODS: we used two different methods of estimation of the amount of microvessels in the series of 55 cases, e.g. classical count of endothelial cells group (h-MVD) and digital image measurement of the vessel density (VD). RESULTS: neither h-MVD nor VD correlated significantly with clinical features of the tumour. The results of VD examination correlated significantly with the existence of nodal metastases (P=0.02). The relationship between h-MVD and N status was on the statistical borderline (P=0.07). Multivariate analysis of Cox's proportional hazards model revealed that only N status correlated significantly with patients' survival. CONCLUSION: our results indicate that measurements of angiogenesis in laryngeal cancer may be of some value in predicting N status in laryngeal cancerpatients. This issue should be confirmed in prospective studies.
Authors: Matvey Sprindzuk; Alexander Dmitruk; Vassili Kovalev; Armen Bogush; Alexander Tuzikov; Victor Liakhovski; Mikhail Fridman Journal: J Clin Med Res Date: 2009-12-28
Authors: Anke Schlüter; Patrick Weller; Oliver Kanaan; Ivonne Nel; Lukas Heusgen; Benedikt Höing; Pia Haßkamp; Sebastian Zander; Magis Mandapathil; Nina Dominas; Judith Arnolds; Boris A Stuck; Stephan Lang; Agnes Bankfalvi; Sven Brandau Journal: BMC Cancer Date: 2018-03-09 Impact factor: 4.430