Literature DB >> 12166999

A novel pyrrolidinyl PNA showing high sequence specificity and preferential binding to DNA over RNA.

Tirayut Vilaivan1, Gordon Lowe.   

Abstract

A novel conformationally constrained pyrrolidinyl peptide nucleic acid (PNA) carrying an D-aminopyrrolidine carboxylic acid (D-Apc) spacer was synthesized, and its interactions with complementary oligo- and polynucleotides were studied by UV and CD spectroscopy. The decathymine PNA formed very stable PNA-DNA complexes with poly(dA) and (dA)(10) by a sequence-specific A-T pairing. The interaction with poly(rA) gave the corresponding PNA-RNA complex with much lower stability.

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Year:  2002        PMID： 12166999     DOI： 10.1021/ja012543u

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  3 in total

1.  Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone: A conformationally constrained PNA with unusual hybridization properties.

Authors:  Chotima Vilaivan; Choladda Srisuwannaket; Cheeraporn Ananthanawat; Chaturong Suparpprom; Junji Kawakami; Yoshie Yamaguchi; Yuko Tanaka; Tirayut Vilaivan
Journal:  Artif DNA PNA XNA       Date:  2011-04

Review 2.  Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.

Authors:  Chaturong Suparpprom; Tirayut Vilaivan
Journal:  RSC Chem Biol       Date:  2022-03-18

3.  Conformational Control of Dual Emission by Pyrrolidinyl PNA-DNA Hybrids.

Authors:  Sabrina Sezi; Reji Varghese; Tirayut Vilaivan; Hans-Achim Wagenknecht
Journal:  ChemistryOpen       Date:  2012-07-11       Impact factor: 2.911
  3 in total

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