Literature DB >> 12166957

Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays.

Achim Freisleben1, Peter Schieberle, Michael Rychlik.   

Abstract

[2H4]Folic acid was synthesized by deuterating p-aminobenzoic acid, which was then coupled to glutamic acid and 6-formylpterin. Using [2H4]folic acid as starting component enabled the preparation of labeled vitamers tetrahydrofolate, 5-formyltetrahydrofolate, 5-methyltetrahydrofolate, and 10-formylfolate which were characterized by electrospray mass spectrometry and collision-induced dissociation. The mass spectrometric studies confirmed that the compounds could be used as internal standards in stable isotope dilution assays.

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Year:  2002        PMID： 12166957     DOI： 10.1021/jf025571k

Source DB:  PubMed          Journal:  J Agric Food Chem        ISSN： 0021-8561            Impact factor:   5.279


  8 in total

1.  Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.

Authors:  Ying Zhao; William R Shadrick; Miranda J Wallace; Yinan Wu; Elizabeth C Griffith; Jianjun Qi; Mi-Kyung Yun; Stephen W White; Richard E Lee
Journal:  Bioorg Med Chem Lett       Date:  2016-07-04       Impact factor: 2.823

2.  (2Z)-2-Anilino-2-[oxido(phen-yl)iminio]-N-(2-pyrid-yl)acetamide methanol 0.425-solvate.

Authors:  Maciej Hodorowicz; Katarzyna Stadnicka; Bartosz Trzewik; Barbara Zaleska
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-02-15

3.  Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies.

Authors:  Markus Kopp; Rosalie Morisset; Peter Koehler; Michael Rychlik
Journal:  PLoS One       Date:  2016-06-08       Impact factor: 3.240

4.  Measurements of Intra- and Extra-Cellular 5-Methyltetrahydrofolate Indicate that Bifidobacterium Adolescentis DSM 20083T and Bifidobacterium Pseudocatenulatum DSM 20438T Do Not Actively Excrete 5-Methyltetrahydrofolate In vitro.

Authors:  Markus Kopp; Kerstin Dürr; Matthias Steigleder; Thomas Clavel; Michael Rychlik
Journal:  Front Microbiol       Date:  2017-03-21       Impact factor: 5.640

Review 5.  Challenges to Quantify Total Vitamin Activity: How to Combine the Contribution of Diverse Vitamers?

Authors:  Jette Jakobsen; Alida Melse-Boonstra; Michael Rychlik
Journal:  Curr Dev Nutr       Date:  2019-07-25

6.  Pilot Study on Folate Bioavailability from a Camembert Cheese Reveals Contradictory Findings to Recent Results from a Human Short-term Study.

Authors:  Sabine Mönch; Michael Netzel; Gabriele Netzel; Undine Ott; Thomas Frank; Michael Rychlik
Journal:  Front Nutr       Date:  2016-04-08

7.  Quantitation of 5-Methyltetrahydrofolic Acid in Dried Blood Spots and Dried Plasma Spots by Stable Isotope Dilution Assays.

Authors:  Markus Kopp; Michael Rychlik
Journal:  PLoS One       Date:  2015-11-25       Impact factor: 3.240

8.  Simulation of Food Folate Digestion and Bioavailability of an Oxidation Product of 5-Methyltetrahydrofolate.

Authors:  Christiane Ringling; Michael Rychlik
Journal:  Nutrients       Date:  2017-09-01       Impact factor: 5.717
  8 in total

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