Literature DB >> 12164277

Protective effect of a plant formula on ethanol-induced gastric lesions in rats.

Min Zhu1, Katherine T Lew, Po-Lau Leung.   

Abstract

A plant formula and its five components were evaluated independently for their gastric protective effect against ethanol-induced stomach lesions in rats. Aqueous extracts of the plant formula (0.25-2g crude drug/kg orally) and its individual components (at the same dose) all showed significant stomach protective effects dose dependently. However, when these extracts were given to rats at a dose of 0.25 g/kg, the five single-herb preparations did not show any activity, but the formula-extract still exhibited a strong protective effect. These findings suggest the presence of a synergistic effect among the plant components. Chemical examination of the extracts indicated that the major ingredients of the five plants were essential oils, terpenoids, flavonoids, glycosides and saccharides and these may contribute to the stomach protective activity observed.

Entities:  

Mesh：

Substances：

Year:  2002        PMID： 12164277     DOI： 10.1002/ptr.839

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  10 in total

1.  Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine "Li-Yan Zhi-Ke Granule" for relieving chronic pharyngitis in rats.

Authors:  Yiyi Sun; Zhihe Zang; Xiaohong Xu; Zhonglin Zhang; Ling Zhong; Wang Zan; Yan Zhao; Lin Sun
Journal:  Mol Biol Rep       Date:  2010-03-28       Impact factor: 2.316

2.  Safety investigation on total steroid saponins extracts from Dioscorea zingiberensis C.H. Wright: Sub-acute and chronic toxicity studies on dogs.

Authors:  Xinxin Zhang; Ming Jin; Nigatu Tadesse; Liang Xian; Hui Zhang; Sicen Wang; Jun Dang; Yan Zhang; Zengjun Guo; Yoichiro Ito
Journal:  Regul Toxicol Pharmacol       Date:  2017-10-21       Impact factor: 3.271

3.  Effect of oral administration of aqueous whole extract of cassytha filiformis on haematograms and plasma biochemical parameters in rats.

Authors:  Hausatu M Babayi; Joseph J I Udeme; Joseph A Abalaka; Joseph I Okogun; O A Salawu; David D Akumka; Sunday S Zarma; Bulus B Adzu; Sabo S Abdulmumuni; Kolo Ibrahime; Baba B Elisha; Samuel S Zakariys; Uford S Inyang
Journal:  J Med Toxicol       Date:  2007-12

4.  Investigation into the toxicity of traditional Uyghur medicine Quercus infectoria galls water extract.

Authors:  Mubarak Iminjan; Nurmuhammat Amat; Xiao-Hui Li; Halmurat Upur; Dilnur Ahmat; Bin He
Journal:  PLoS One       Date:  2014-03-07       Impact factor: 3.240

5.  Evaluation of acute and sub-chronic oral toxicity study of Baker Cleansers Bitters - a polyherbal drug on experimental rats.

Authors:  K C Patrick-Iwuanyanwu; U Amadi; I A Charles; E O Ayalogu
Journal:  EXCLI J       Date:  2012-09-11       Impact factor: 4.068

6.  Anticholinesterase and antioxidant potentials of Nonea micrantha Bioss. & Reut along with GC-MS analysis.

Authors:  Muhammad Imran; Farhat Ullah; Muhammad Ayaz; Abdul Sadiq; Muhammad Raza Shah; Muhammad Saeed Jan; Farman Ullah
Journal:  BMC Complement Altern Med       Date:  2017-11-23       Impact factor: 3.659

7.  Safety assessment of the methanol extract of the stem bark of Amphimas pterocarpoides Harms: Acute and subchronic oral toxicity studies in Wistar rats.

Authors:  Job Tchoumtchoua; Oumarou Riepouo Mouchili; Sylvin Benjamin Ateba; Stéphane Zingue; Maria Halabalaki; Jean Claude Mbanya; Alexios-Leandros Skaltsounis; Dieudonné Njamen
Journal:  Toxicol Rep       Date:  2014-10-16

8.  Evaluation of cytotoxic effects and acute and chronic toxicity of aqueous extract of the seeds of Calycotome villosa (Poiret) Link (subsp. intermedia) in rodents.

Authors:  Badiaa Lyoussi; Khadija Cherkaoui Tangi; Nicole Morel; Mohamed Haddad; Joelle Quetin-Leclercq
Journal:  Avicenna J Phytomed       Date:  2018 Mar-Apr

9.  Efficacy of a Peruvian Botanical Remedy (Sabell A4+) for Treating Liver Disease and Protecting Gastric Mucosal Integrity.

Authors:  Mark G Swain; John L Wallace; D Lorne Tyrrell; José Cabanillas; Steven K H Aung; Hongqun Liu; Lindsay Finnie-Carvalho; Grishma Shrestha; Hugh A Semple; Francis H Y Green
Journal:  Evid Based Complement Alternat Med       Date:  2019-10-24       Impact factor: 2.629

10.  In Vitro and In Vivo Toxicity Studies on Cymbopogon giganteus Chiov. Leaves Essential Oil from Benin.

Authors:  Habib Toukourou; Francine Uwambayinema; Yousof Yakoub; Birgit Mertens; Anatole Laleye; Dominique Lison; Joelle Quetin-Leclercq; Fernand Gbaguidi
Journal:  J Toxicol       Date:  2020-01-28
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.