Literature DB >> 12164218

Synthesis and antituberculosis activity of new N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thioureas.

S Karakuş1, S Rollas.   

Abstract

In this study, eight original N-phenyl-N'-[4-(5-alkyl/arylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea derivatives were synthesized and tested for antituberculosis activity. Antituberculosis activities of the synthesized compounds were screened in vitro using BACTEC 460 Radiometric System against Mycobacterium tuberculosis H37Rv at 6.25 microg/ml. The highest inhibition observed with the synthesized compounds is 67% for N-phenyl-N'-[4-(5-cyclohexylamino-1,3,4-thiadiazole-2-yl)phenyl]thiourea.

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Year:  2002        PMID： 12164218     DOI： 10.1016/s0014-827x(02)01252-1

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  8 in total

1.  High pressure liquid chromatographic analysis of in vivo metabolites of N-(substituted phenyl)-N'-(1,3,5-trimethyl pyrazole-4-yl)thioureas in rats.

Authors:  Bedia Kocyigit-Kaymakcioglu; Ufuk Yilmaz; Feyza Aricioglu
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2007 Oct-Dec       Impact factor: 2.441

2.  1-{[(Z)-Cyclo-pentyl-idene]amino}-3-phenyl-thio-urea.

Authors:  Joel T Mague; Shaaban K Mohamed; Mehmet Akkurt; Alaa A Hassan; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-04-05

Review 3.  Synthetic methods, chemistry, and the anticonvulsant activity of thiadiazoles.

Authors:  Bhawna Sharma; Amita Verma; Sunil Prajapati; Upendra Kumar Sharma
Journal:  Int J Med Chem       Date:  2013-04-30

Review 4.  2-Amino-1,3,4-thiadiazole as a potential scaffold for promising antimicrobial agents.

Authors:  Georgeta Serban; Oana Stanasel; Sanda Bota; Eugenia Serban
Journal:  Drug Des Devel Ther       Date:  2018-05-31       Impact factor: 4.162

5.  New Route Synthesis of Thiadiazoles, Bisthiadiazoles, Thiadiazolotriazines, and Pyrazolothiadiazoles Based on Hydrazonoyl Halides and Dihydrazinylthiadiazole.

Authors:  Abdelwahed R Sayed; Shar Saad Al-Shihry
Journal:  Molecules       Date:  2017-02-21       Impact factor: 4.411

6.  Synthesis, spectroscopic properties and antipathogenic activity of new thiourea derivatives.

Authors:  Carmen Limban; Luminita Marutescu; Mariana Carmen Chifiriuc
Journal:  Molecules       Date:  2011-09-06       Impact factor: 4.411

7.  Crystal structure of tetra-μ-acetato-bis-[(5-amino-2-methyl-sulfanyl-1,3,4-thia-diazole-κN 1)copper(II)].

Authors:  Batirbay Torambetov; Shaxnoza Kadirova; Turdibek Toshmurodov; Jamshid Mengnorovich Ashurov; Nusrat Agzamovich Parpiev; Abdukhakim Ziyaev
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-07-23

8.  Synthesis, Characterization, and In Vivo Study of Some Novel 3,4,5-Trimethoxybenzylidene-hydrazinecarbothioamides and Thiadiazoles as Anti-Apoptotic Caspase-3 Inhibitors.

Authors:  Sara M Mostafa; Ashraf A Aly; Stefan Bräse; Martin Nieger; Sara Mohamed Naguib Abdelhafez; Walaa Yehia Abdelzaher; El-Shimaa M N Abdelhafez
Journal:  Molecules       Date:  2022-03-31       Impact factor: 4.927
  8 in total

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