Literature DB >> 12163616

Decelerating decay of latently infected cells during prolonged therapy for human immunodeficiency virus type 1 infection.

Viktor Müller1, Javier Flavio Vigueras-Gómez, Sebastian Bonhoeffer.   

Abstract

Antiviral therapy induces a rapid drop in human immunodeficiency virus type 1 viremia, but the decline of virus levels decelerates over time. Mathematical modeling demonstrates that the source of residual virus production might be a single compartment of latently infected cells with an extended distribution of activation rates.

Entities:  

Mesh：

Year:  2002        PMID： 12163616      PMCID： PMC136417          DOI： 10.1128/jvi.76.17.8963-8965.2002

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  Ongoing HIV dissemination during HAART.

Authors:  Z Grossman; M Polis; M B Feinberg; Z Grossman; I Levi; S Jankelevich; R Yarchoan; J Boon; F de Wolf; J M Lange; J Goudsmit; D S Dimitrov; W E Paul
Journal:  Nat Med       Date:  1999-10       Impact factor: 53.440

2.  A stable latent reservoir for HIV-1 in resting CD4(+) T lymphocytes in infected children.

Authors:  D Persaud; T Pierson; C Ruff; D Finzi; K R Chadwick; J B Margolick; A Ruff; N Hutton; S Ray; R F Siliciano
Journal:  J Clin Invest       Date:  2000-04       Impact factor: 14.808

Review 3.  Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy.

Authors:  T Pierson; J McArthur; R F Siliciano
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

4.  Antigen-driven CD4+ T cell and HIV-1 dynamics: residual viral replication under highly active antiretroviral therapy.

Authors:  N M Ferguson; F deWolf; A C Ghani; C Fraser; C A Donnelly; P Reiss; J M Lange; S A Danner; G P Garnett; J Goudsmit; R M Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

5.  HIV-1 dynamics revisited: biphasic decay by cytotoxic T lymphocyte killing?

Authors:  R A Arnaout; M A Nowak; D Wodarz
Journal:  Proc Biol Sci       Date:  2000-07-07       Impact factor: 5.349

6.  Characterization of chemokine receptor utilization of viruses in the latent reservoir for human immunodeficiency virus type 1.

Authors:  T Pierson; T L Hoffman; J Blankson; D Finzi; K Chadwick; J B Margolick; C Buck; J D Siliciano; R W Doms; R F Siliciano
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

7.  Re-emergence of HIV after stopping therapy.

Authors:  T W Chun; R T Davey; D Engel; H C Lane; A S Fauci
Journal:  Nature       Date:  1999-10-28       Impact factor: 49.962

8.  HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression.

Authors:  R T Davey; N Bhat; C Yoder; T W Chun; J A Metcalf; R Dewar; V Natarajan; R A Lempicki; J W Adelsberger; K D Miller; J A Kovacs; M A Polis; R E Walker; J Falloon; H Masur; D Gee; M Baseler; D S Dimitrov; A S Fauci; H C Lane
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

9.  The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy.

Authors:  B Ramratnam; J E Mittler; L Zhang; D Boden; A Hurley; F Fang; C A Macken; A S Perelson; M Markowitz; D D Ho
Journal:  Nat Med       Date:  2000-01       Impact factor: 53.440

10.  Effect of influenza vaccination on viral replication and immune response in persons infected with human immunodeficiency virus receiving potent antiretroviral therapy.

Authors:  H F Günthard; J K Wong; C A Spina; C Ignacio; S Kwok; C Christopherson; J Hwang; R Haubrich; D Havlir; D D Richman
Journal:  J Infect Dis       Date:  2000-02       Impact factor: 5.226
View more
  11 in total

1.  Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence.

Authors:  M C Strain; H F Günthard; D V Havlir; C C Ignacio; D M Smith; A J Leigh-Brown; T R Macaranas; R Y Lam; O A Daly; M Fischer; M Opravil; H Levine; L Bacheler; C A Spina; D D Richman; J K Wong
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-08       Impact factor: 11.205

2.  Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy.

Authors:  Christian L Althaus; Rob J De Boer
Journal:  Mol Syst Biol       Date:  2010-02-16       Impact factor: 11.429

Review 3.  Modeling HIV persistence, the latent reservoir, and viral blips.

Authors:  Libin Rong; Alan S Perelson
Journal:  J Theor Biol       Date:  2009-06-17       Impact factor: 2.691

4.  Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir.

Authors:  Ahmad R Sedaghat; Robert F Siliciano; Claus O Wilke
Journal:  Antivir Ther       Date:  2009

5.  Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips.

Authors:  Libin Rong; Alan S Perelson
Journal:  Math Biosci       Date:  2008-10-17       Impact factor: 2.144

6.  A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients.

Authors:  Jessica M Conway; Daniel Coombs
Journal:  PLoS Comput Biol       Date:  2011-04-28       Impact factor: 4.475

7.  Viral and latent reservoir persistence in HIV-1-infected patients on therapy.

Authors:  Hwijin Kim; Alan S Perelson
Journal:  PLoS Comput Biol       Date:  2006-08-28       Impact factor: 4.475

8.  Quantifying the turnover of transcriptional subclasses of HIV-1-infected cells.

Authors:  Christian L Althaus; Beda Joos; Alan S Perelson; Huldrych F Günthard
Journal:  PLoS Comput Biol       Date:  2014-10-23       Impact factor: 4.475

9.  Modeling latently infected cell activation: viral and latent reservoir persistence, and viral blips in HIV-infected patients on potent therapy.

Authors:  Libin Rong; Alan S Perelson
Journal:  PLoS Comput Biol       Date:  2009-10-16       Impact factor: 4.475

10.  Low-level HIV-1 replication and the dynamics of the resting CD4+ T cell reservoir for HIV-1 in the setting of HAART.

Authors:  Ahmad R Sedaghat; Robert F Siliciano; Claus O Wilke
Journal:  BMC Infect Dis       Date:  2008-01-02       Impact factor: 3.090
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.