| Literature DB >> 12163271 |
Berran Yucesoy1, Annemarie Sleijffers, Michael Kashon, Johan Garssen, Frank R de Gruijl, Greet J Boland, Jan van Hattum, Petia P Simeonova, Michael I Luster, Henk van Loveren.
Abstract
Considerable variability exists in the vaccine response to hepatitis B with 5-10% of healthy young adults demonstrating no or inadequate responses following a standard vaccination schedule. As the interleukin-1beta (IL-1beta) cytokine has been shown to be important in the development of immune responses, we determined whether vaccine efficacy is influenced by genetic polymorphisms associated with IL-1beta expression. Ninety-two healthy individuals who were negative for antibodies to hepatitis B antigen (anti-HBs) were vaccinated against hepatitis B according to a standardized schedule. At selected times, antibody titers and lymphoproliferative capacity to hepatitis B surface antigen (HBsAg) were determined. DNA genotyping for IL-1beta polymorphisms using a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique demonstrated that both the anti-HBs titer and the T-cell lymphoproliferative response to HBsAg are significantly increased in individuals possessing the IL-1beta (+3953) minor allelic variant. Copyright 2002 Elsevier Science Ltd.Entities:
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Year: 2002 PMID： 12163271 DOI： 10.1016/s0264-410x(02)00267-0
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641