The ovarian gap junction protein connexin43: regulation by gonadotropins.

The major role of the ovarian follicle is the timely production of a mature fertilizable oocyte. This mission is accomplished by a gonadotropin-regulated, gap junction-mediated alteration between established and interrupted cell-cell communication. Recent studies have revealed that gonadotropin action on ovarian gap junctions is elicited at the transcriptional, translational and post-translational levels. Here, we review the existing information generated on the molecular mechanisms employed by the gonadotropins to elicit their effect on the ovarian gap junction protein Cx43.