Literature DB >> 12163108

Differential trafficking of the vesicular monoamine transporter-2 by methamphetamine and cocaine.

Evan L Riddle1, Matthew K Topham, John W Haycock, Glen R Hanson, Annette E Fleckenstein.   

Abstract

High-dose administration of cocaine or methamphetamine to rats acutely (< or = 24 h) alters vesicular dopamine transport. This study elucidates the nature of these changes. Results reveal a differential redistribution of the vesicular monoamine transporter-2 (VMAT-2) within striatal synaptic terminals after drug treatment. In particular, cocaine shifts VMAT-2 protein from a synaptosomal membrane fraction to a vesicle-enriched fraction, as assessed ex vivo in fractions prepared from treated rats. In contrast, methamphetamine treatment redistributes VMAT-2 from a vesicle-enriched fraction to a location that is not retained in a synaptosomal preparation. These data suggest that psychostimulants acutely and differentially affect VMAT-2 subcellular localization.

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Year:  2002        PMID： 12163108     DOI： 10.1016/s0014-2999(02)01985-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  45 in total

1.  Methamphetamine alters vesicular monoamine transporter-2 function and potassium-stimulated dopamine release.

Authors:  Pei-Wen Chu; Gregory C Hadlock; Paula Vieira-Brock; Kristen Stout; Glen R Hanson; Annette E Fleckenstein
Journal:  J Neurochem       Date:  2010-08-25       Impact factor: 5.372

2.  Unique genetic factors influence sensitivity to the rewarding and aversive effects of methamphetamine versus cocaine.

Authors:  Noah R Gubner; Cheryl Reed; Carrie S McKinnon; Tamara J Phillips
Journal:  Behav Brain Res       Date:  2013-08-28       Impact factor: 3.332

Review 3.  Causes and consequences of methamphetamine and MDMA toxicity.

Authors:  Maria S Quinton; Bryan K Yamamoto
Journal:  AAPS J       Date:  2006-05-12       Impact factor: 4.009

Review 4.  HIV-1 neuropathogenesis: glial mechanisms revealed through substance abuse.

Authors:  Kurt F Hauser; Nazira El-Hage; Anne Stiene-Martin; William F Maragos; Avindra Nath; Yuri Persidsky; David J Volsky; Pamela E Knapp
Journal:  J Neurochem       Date:  2006-12-01       Impact factor: 5.372

Review 5.  Trafficking of dopamine transporters in psychostimulant actions.

Authors:  Nancy R Zahniser; Alexander Sorkin
Journal:  Semin Cell Dev Biol       Date:  2009-01-22       Impact factor: 7.727

6.  The expression of kainate receptor subunits in hippocampal astrocytes after experimentally induced status epilepticus.

Authors:  Jay R Vargas; D Koji Takahashi; Kyle E Thomson; Karen S Wilcox
Journal:  J Neuropathol Exp Neurol       Date:  2013-10       Impact factor: 3.685

Review 7.  Psychostimulant-induced alterations in vesicular monoamine transporter-2 function: neurotoxic and therapeutic implications.

Authors:  Annette E Fleckenstein; Trent J Volz; Glen R Hanson
Journal:  Neuropharmacology       Date:  2008-07-10       Impact factor: 5.250

8.  Method development and validation of an in vitro model of the effects of methylphenidate on membrane-associated synaptic vesicles.

Authors:  Trent J Volz; Sarah J Farnsworth; Glen R Hanson; Annette E Fleckenstein
Journal:  J Neurosci Methods       Date:  2008-10-17       Impact factor: 2.390

9.  Methylphenidate-induced alterations in synaptic vesicle trafficking and activity.

Authors:  Trent J Volz; Sarah J Farnsworth; Glen R Hanson; Annette E Fleckenstein
Journal:  Ann N Y Acad Sci       Date:  2008-10       Impact factor: 5.691

10.  PEGylation of a High-Affinity Anti-(+)Methamphetamine Single Chain Antibody Fragment Extends Functional Half-Life by Reducing Clearance.

Authors:  Emily E Reichard; Nisha Nanaware-Kharade; Guillermo A Gonzalez; Shraddha Thakkar; S Michael Owens; Eric C Peterson
Journal:  Pharm Res       Date:  2016-09-12       Impact factor: 4.200
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