Literature DB >> 12163037

A new promoter for alpha1C subunit of human L-type cardiac calcium channel Ca(V)1.2.

Bosong Dai1, Nehad Saada, Clement Echetebu, Christine Dettbarn, Philip Palade.   

Abstract

The cardiac Ca channel known as alpha1C or Ca(V)1.2 is shown to express a new longer first exon equivalent to that formerly reported in rabbit heart or rat aorta. Ribonuclease protection assay indicates that this exon is found in the majority of Ca(V)1.2 transcripts in human heart RNA. The presence of this exon also suggests that expression of this transcript is driven by a promoter immediately upstream of this exon and its 5' untranslated region. The putative promoter exhibits 69% homology to its rat counterpart and displays functional promoter activity when transfected into heart cells in culture in luciferase-expressing constructs.

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Year:  2002        PMID： 12163037     DOI： 10.1016/s0006-291x(02)00894-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

1.  Vascular smooth muscle-specific knockdown of the noncardiac form of the L-type calcium channel by microRNA-based short hairpin RNA as a potential antihypertensive therapy.

Authors:  Sung W Rhee; Joseph R Stimers; Wenze Wang; Li Pang
Journal:  J Pharmacol Exp Ther       Date:  2009-02-24       Impact factor: 4.030

2.  Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit.

Authors:  Shimrit Oz; Ines Pankonien; Anouar Belkacemi; Veit Flockerzi; Enno Klussmann; Hannelore Haase; Nathan Dascal
Journal:  J Physiol       Date:  2017-03-23       Impact factor: 5.182

3.  Hippocampal 'zipper' slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging.

Authors:  Christopher M Norris; Eric M Blalock; Kuey-Chu Chen; Nada M Porter; Olivier Thibault; Susan D Kraner; Philip W Landfield
Journal:  Neurobiol Aging       Date:  2010-02       Impact factor: 4.673

4.  CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels.

Authors:  Shimrit Oz; Vladimir Tsemakhovich; Carl J Christel; Amy Lee; Nathan Dascal
Journal:  J Biol Chem       Date:  2011-03-07       Impact factor: 5.157

5.  The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator.

Authors:  John P Bannister; Marie Dennis Leo; Damodaran Narayanan; Wanchana Jangsangthong; Anitha Nair; Kirk W Evanson; Judith Pachuau; Kyle S Gabrick; Frederick A Boop; Jonathan H Jaggar
Journal:  J Physiol       Date:  2013-04-08       Impact factor: 5.182

Review 6.  Autoregulation of cardiac l-type calcium channels.

Authors:  Jonathan Satin; Elizabeth A Schroder
Journal:  Trends Cardiovasc Med       Date:  2009-11       Impact factor: 6.677

7.  Regulation of maximal open probability is a separable function of Ca(v)beta subunit in L-type Ca2+ channel, dependent on NH2 terminus of alpha1C (Ca(v)1.2alpha).

Authors:  Nataly Kanevsky; Nathan Dascal
Journal:  J Gen Physiol       Date:  2006-07       Impact factor: 4.086

Review 8.  CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease.

Authors:  Shambhu Bhat; David T Dao; Chantelle E Terrillion; Michal Arad; Robert J Smith; Nikolai M Soldatov; Todd D Gould
Journal:  Prog Neurobiol       Date:  2012-06-15       Impact factor: 11.685

9.  Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle.

Authors:  Kuicheon Choi; Jinghong Chen; Sankar Mitra; Sushil K Sarna
Journal:  Gastroenterology       Date:  2011-07-13       Impact factor: 22.682

10.  Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, CaV1.2.

Authors:  Tal Keren Raifman; Prabodh Kumar; Hannelore Haase; Enno Klussmann; Nathan Dascal; Sharon Weiss
Journal:  Channels (Austin)       Date:  2017-09-21       Impact factor: 2.581
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