Literature DB >> 12162945

Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.

Mehmet Emin Büyükokuroğlu1.   

Abstract

Our study aimed at examining the possible anti-inflammatory and antinociceptive effects of dantrolene sodium in rats and mice. The anti-inflammatory effect of dantrolene sodium (2.5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests. Analgesic effects of dantrolene sodium were evaluated and compared with metamizol (200 mg kg (-1)) in acetic acid-induced writhing and formalin-induced paw licking tests. It was found that dantrolene sodium significantly diminished the nociceptive response in mice, showing at the same time considerable anti-inflammatory properties in rats.

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Year:  2002        PMID： 12162945     DOI： 10.1006/phrs.2002.0970

Source DB:  PubMed          Journal:  Pharmacol Res        ISSN： 1043-6618            Impact factor:   7.658


  5 in total

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3.  Dantrolene can reduce secondary damage after spinal cord injury.

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Journal:  Clin Neuropharmacol       Date:  2016 Nov/Dec       Impact factor: 1.592
  5 in total

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