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Literature DB >> 12162914

Older adults with acute myeloid leukemia.

Abstract

Acute myeloid leukemia (AML) occurs most frequently in older adults, with a median age range from 65 to 70 years. Both the disease and its treatment are distinct from their counterparts in young patients. Herein we characterize the intrinsic biologic features of AML as it occurs in the older population, review currently available therapeutic approaches, and discuss therapeutic strategies in development.

Entities: Disease Species

Mesh：

Substances：

Year: 2002 PMID： 12162914 DOI： 10.1007/s11912-002-0034-y

Source DB: PubMed Journal: Curr Oncol Rep ISSN： 1523-3790 Impact factor: 5.075

63 in total

1. De novo and secondary acute myeloid leukemia in patients over the age of 65: a review of fifty-six successive and unselected cases from a general hospital.

Authors: F Bauduer; L Ducout; N Dastugue; C Capdupuy; M Renoux
Journal: Leuk Lymphoma Date: 1999-10

2. Microsatellite instability and p53 mutations are associated with abnormal expression of the MSH2 gene in adult acute leukemia.

Authors: Y M Zhu; E P Das-Gupta; N H Russell
Journal: Blood Date: 1999-07-15 Impact factor: 22.113

Review 3. Non-myeloablative transplants for malignant disease.

Authors: R F Storb; R Champlin; S R Riddell; M Murata; S Bryant; E H Warren
Journal: Hematology Am Soc Hematol Educ Program Date: 2001

4. A placebo-controlled study of recombinant human granulocyte-macrophage colony-stimulating factor administered during and after induction treatment for de novo acute myelogenous leukemia in elderly patients. Groupe Ouest Est Leucémies Aiguës Myéloblastiques (GOELAM).

Authors: F Witz; A Sadoun; M C Perrin; C Berthou; J Brière; J Y Cahn; B Lioure; B Witz; S François; B Desablens; B Pignon; P Y Le Prisé; B Audhuy; D Caillot; P Casassus; M Delain; B Christian; Z Tellier; V Polin; P Hurteloup; J L Harousseau
Journal: Blood Date: 1998-04-15 Impact factor: 22.113

5. A phase I study of induction chemotherapy for older patients with newly diagnosed acute myeloid leukemia (AML) using mitoxantrone, etoposide, and the MDR modulator PSC 833: a southwest oncology group study 9617.

Authors: T R Chauncey; C Rankin; J E Anderson; I Chen; K J Kopecky; J E Godwin; M E Kalaycio; D F Moore; M S Shurafa; S H Petersdorf; E H Kraut; C P Leith; D R Head; F W Luthardt; C L Willman; F R Appelbaum
Journal: Leuk Res Date: 2000-07 Impact factor: 3.156

6. Cytogenetic analogy between myelodysplastic syndrome and acute myeloid leukemia of elderly patients.

Authors: G Rossi; A M Pelizzari; D Bellotti; M Tonelli; S Barlati
Journal: Leukemia Date: 2000-04 Impact factor: 11.528

7. Comparison of three remission induction regimens and two postinduction strategies for the treatment of acute nonlymphocytic leukemia: a cancer and leukemia group B study.

Authors: H Preisler; R B Davis; J Kirshner; E Dupre; F Richards; H C Hoagland; S Kopel; R N Levy; R Carey; P Schulman
Journal: Blood Date: 1987-05 Impact factor: 22.113

8. Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia.

Authors: P H Wiernik; P L Banks; D C Case; Z A Arlin; P O Periman; M B Todd; P S Ritch; R E Enck; A B Weitberg
Journal: Blood Date: 1992-01-15 Impact factor: 22.113

9. A randomized placebo-controlled phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490).

Authors: J M Rowe; J W Andersen; J J Mazza; J M Bennett; E Paietta; F A Hayes; D Oette; P A Cassileth; E A Stadtmauer; P H Wiernik
Journal: Blood Date: 1995-07-15 Impact factor: 22.113