PURPOSE:Physical properties and tear film function were investigated for a multipurpose contact lens solution containing the ocular lubricant hydroxypropyl methylcellulose (HPMC). METHODS: In the laboratory, wetting properties of multipurpose solutions with and without HPMC, and binding of HPMC to hydrogel lenses in vitro following an overnight soak, were measured. Tear physiology was evaluated in 35 hydrogel contact lens wearers usingmultipurpose solutions with and without HPMC. Pre-lens tear evaporation rate (TER), tear thinning time (TTT) and tear film structure (TFS) were recorded, and subjective responses were obtained. RESULTS: Laboratory measurements indicated improved wetting with the HPMC-containing solution, and continued release of HPMC from lenses after an overnight soak in the solution. Pre-lens TTT was longer (p < 0.001) and pre-lens TFS was improved (p = 0.034) with use of the HPMC-containing solution. Pre-lens TER and subjective comparisons did not demonstrate significant differences. CONCLUSIONS: In vitro and in vivo results are consistent with HPMC producing a thicker, longer-lasting layer of fluid on the hydrogel lens, leading to improvements in tear function in contact lens wearers.
RCT Entities:
PURPOSE: Physical properties and tear film function were investigated for a multipurpose contact lens solution containing the ocular lubricant hydroxypropyl methylcellulose (HPMC). METHODS: In the laboratory, wetting properties of multipurpose solutions with and without HPMC, and binding of HPMC to hydrogel lenses in vitro following an overnight soak, were measured. Tear physiology was evaluated in 35 hydrogel contact lens wearers using multipurpose solutions with and without HPMC. Pre-lens tear evaporation rate (TER), tear thinning time (TTT) and tear film structure (TFS) were recorded, and subjective responses were obtained. RESULTS: Laboratory measurements indicated improved wetting with the HPMC-containing solution, and continued release of HPMC from lenses after an overnight soak in the solution. Pre-lens TTT was longer (p < 0.001) and pre-lens TFS was improved (p = 0.034) with use of the HPMC-containing solution. Pre-lens TER and subjective comparisons did not demonstrate significant differences. CONCLUSIONS: In vitro and in vivo results are consistent with HPMC producing a thicker, longer-lasting layer of fluid on the hydrogel lens, leading to improvements in tear function in contact lens wearers.
Authors: Fiona Stapleton; Carl Marfurt; Blanka Golebiowski; Mark Rosenblatt; David Bereiter; Carolyn Begley; Darlene Dartt; Juana Gallar; Carlos Belmonte; Pedram Hamrah; Mark Willcox Journal: Invest Ophthalmol Vis Sci Date: 2013-10-18 Impact factor: 4.799