Literature DB >> 12161566

Sperm donor suffers years later from inherited disease.

D O E Gebhardt1.   

Abstract

A case is described of a man who discovered years after donating sperm for artificial insemination, that he had a serious genetic disease, autosomal dominant cerebellar ataxia (ADCA). This manifests itself only years after puberty and occurs in 50% of the progeny. The sperm had been used for the conception of 18 children in 13 women. The parents were only told three years after the insemination. This long time interval was unavoidable since many of the parents had to be found and the hospital director wished first to discuss the matter with his legal advisors and other experts. In future, in agreement with the new law only 10 inseminations will take place with sperm from one donor. This will reduce still further the availability of donor sperm.

Entities:  

Keywords:  Genetics and Reproduction

Mesh:

Year:  2002        PMID: 12161566      PMCID: PMC1733629          DOI: 10.1136/jme.28.4.213

Source DB:  PubMed          Journal:  J Med Ethics        ISSN: 0306-6800            Impact factor:   2.903


  6 in total

Review 1.  Clinical and molecular advances in autosomal dominant cerebellar ataxias: from genotype to phenotype and physiopathology.

Authors:  G Stevanin; A Dürr; A Brice
Journal:  Eur J Hum Genet       Date:  2000-01       Impact factor: 4.246

2.  Adult onset neurological disorders. Predictive genetic testing.

Authors:  M Delatycki; R Tassicker
Journal:  Aust Fam Physician       Date:  2001-10

3.  The role of the church in developing the law.

Authors:  L Skene; M Parker
Journal:  J Med Ethics       Date:  2002-08       Impact factor: 2.903

4.  Gamete donation guidelines. The Corsendonk consensus document for the European Union.

Authors:  C Barratt; Y Englert; C Gottlieb; P Jouannet
Journal:  Hum Reprod       Date:  1998-02       Impact factor: 6.918

5.  Should gamete donors be tested for spinal muscular atrophy?

Authors:  Eduardo F Tizzano; Ivón Cuscó; María Jesús Barceló; Juan Parra; Montserrat Baiget
Journal:  Fertil Steril       Date:  2002-02       Impact factor: 7.329

6.  Frequency of spinocerebellar ataxia types 1, 2, 3, 6, and 7 in Australian patients with spinocerebellar ataxia.

Authors:  E Storey; D du Sart; J H Shaw; P Lorentzos; L Kelly; R J McKinley Gardner; S M Forrest; I Biros; G A Nicholson
Journal:  Am J Med Genet       Date:  2000-12-11
  6 in total
  1 in total

1.  The sperm's tale.

Authors:  Mark A Jobling
Journal:  Investig Genet       Date:  2014-06-18
  1 in total

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