Literature DB >> 12161543

Comment: CAPN10 alleles are associated with polycystic ovary syndrome.

Alejandro Gonzalez1, Eduardo Abril, Alfredo Roca, Maria José Aragón, Maria José Figueroa, Pilar Velarde, José Luis Royo, Luis Miguel Real, Agustín Ruiz.   

Abstract

Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation infertility, hyperandrogenemia, and frequently insulin resistance. This study investigated whether polymorphisms in the CAPN10 gene are related with PCOS etiology. The allelic frequencies and genotypes of CAPN10 polymorphisms UCSNP-44, 43, 19, and 63 were determined in 55 well characterized women with polycystic ovaries and 93 unrelated healthy controls using spectrofluorimetric analyses and real-time PCR. Our data indicate that CAPN10 UCSNP-44 allele is associated with PCOS in the Spanish population (P = 0.01). These results support a role of Calpain 10 gene in PCOS susceptibility in humans.

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Year:  2002        PMID： 12161543     DOI： 10.1210/jcem.87.8.8793

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  22 in total

1.  Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility.

Authors:  Michael N Weedon; Peter E H Schwarz; Yukio Horikawa; Naoko Iwasaki; Thomas Illig; Rolf Holle; Wolfgang Rathmann; Thomas Selisko; Jan Schulze; Katherine R Owen; Julie Evans; Laura Del Bosque-Plata; Graham Hitman; Mark Walker; Jonathan C Levy; Mike Sampson; Graeme I Bell; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Journal:  Am J Hum Genet       Date:  2003-11       Impact factor: 11.025

Review 2.  Understanding polycystic ovarian syndrome pathogenesis: an updated of its genetic aspects.

Authors:  A E Calogero; V Calabrò; M Catanuso; R A Condorelli; S La Vignera
Journal:  J Endocrinol Invest       Date:  2011-05-23       Impact factor: 4.256

Review 3.  Genetic variants associated with insulin signaling and glucose homeostasis in the pathogenesis of insulin resistance in polycystic ovary syndrome: a systematic review.

Authors:  Bhaskar Venkata Kameswara Subrahmanya Lakkakula; Maheswari Thangavelu; Usha Rani Godla
Journal:  J Assist Reprod Genet       Date:  2013-06-22       Impact factor: 3.412

4.  Microarray profiling for differential gene expression in ovaries and ovarian follicles of pigs selected for increased ovulation rate.

Authors:  Alexandre Rodrigues Caetano; Rodger K Johnson; J Joe Ford; Daniel Pomp
Journal:  Genetics       Date:  2004-11       Impact factor: 4.562

5.  Genetics of polycystic ovary syndrome.

Authors:  N Prapas; A Karkanaki; I Prapas; I Kalogiannidis; I Katsikis; D Panidis
Journal:  Hippokratia       Date:  2009-10       Impact factor: 0.471

6.  Characterization of endogenous and recombinant human calpain-10.

Authors:  Biao Dong; Rihe Liu
Journal:  Biochimie       Date:  2008-04-10       Impact factor: 4.079

Review 7.  Genetics of the polycystic ovary syndrome.

Authors:  Gülüm Kosova; Margrit Urbanek
Journal:  Mol Cell Endocrinol       Date:  2012-10-16       Impact factor: 4.102

8.  Common polymorphisms of calpain-10 and the risk of polycystic ovary syndrome in Tunisian population: a case-control study.

Authors:  Assila Ben Salem; Redha Attaoua; Nabil Mtiraoui; Sana Belkahla; Intissar Ezzidi; Mounir Ajina; Moncef Souissi; Patrick Poucheret; Madalina Vintila; Florin Grigorescu; Touhami Mahjoub
Journal:  Mol Biol Rep       Date:  2014-07-04       Impact factor: 2.316

Review 9.  Genetic and environmental aspect of polycystic ovary syndrome.

Authors:  E Carmina
Journal:  J Endocrinol Invest       Date:  2003-11       Impact factor: 4.256

10.  Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.

Authors:  Tugba Unsal; Ece Konac; Ediz Yesilkaya; Akin Yilmaz; Aysun Bideci; Hacer Ilke Onen; Peyami Cinaz; Adnan Menevse
Journal:  J Assist Reprod Genet       Date:  2009-04-22       Impact factor: 3.412
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