Literature DB >> 12161164

Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase.

Gillian M Nicholas1, Lisa L Eckman, Satyajit Ray, Robert O Hughes, Jeffrey A Pfefferkorn, Sofia Barluenga, K C Nicolaou, Carole A Bewley.   

Abstract

A series of bromotyrosine-derived compounds, including marine natural products and members of a psammaplin A-inspired combinatorial synthetic library, were screened for their ability to inhibit the Mycobacterium tuberculosis detoxification enzyme mycothiol-S-conjugate amidase (MCA). Correlations between the structures and their respective IC(50) values (which range from 3 microM to 2.7 mM) should prove valuable when optimizing more potent inhibitors of MCA.

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Year:  2002        PMID： 12161164     DOI： 10.1016/s0960-894x(02)00385-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

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2.  Psammaplin a improves development and quality of somatic cell nuclear transfer mouse embryos.

Authors:  Anna Mallol; Josep Santaló; Elena Ibáñez
Journal:  Cell Reprogram       Date:  2014-07-28       Impact factor: 1.987

Review 3.  New targets and inhibitors of mycobacterial sulfur metabolism.

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Journal:  Infect Disord Drug Targets       Date:  2013-04

Review 4.  Bacillithiol: a key protective thiol in Staphylococcus aureus.

Authors:  Varahenage R Perera; Gerald L Newton; Kit Pogliano
Journal:  Expert Rev Anti Infect Ther       Date:  2015-07-16       Impact factor: 5.091

5.  Oxonium Ion Mediated Synthesis of 4-Substituted Spiro-Isoxazolines.

Authors:  Eric McClendon; Ann O Omollo; Edward J Valente; Ashton T Hamme
Journal:  Tetrahedron Lett       Date:  2009-02-04       Impact factor: 2.415

6.  Psammaplin A inhibits hepatitis C virus NS3 helicase.

Authors:  Kazi Abdus Salam; Atsushi Furuta; Naohiro Noda; Satoshi Tsuneda; Yuji Sekiguchi; Atsuya Yamashita; Kohji Moriishi; Masamichi Nakakoshi; Masayoshi Tsubuki; Hidenori Tani; Junichi Tanaka; Nobuyoshi Akimitsu
Journal:  J Nat Med       Date:  2013-01-29       Impact factor: 2.343

Review 7.  Drug targets in mycobacterial sulfur metabolism.

Authors:  Devayani P Bhave; Wilson B Muse; Kate S Carroll
Journal:  Infect Disord Drug Targets       Date:  2007-06

Review 8.  Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria.

Authors:  Gerald L Newton; Nancy Buchmeier; Robert C Fahey
Journal:  Microbiol Mol Biol Rev       Date:  2008-09       Impact factor: 11.056

9.  Functional characterization of Corynebacterium glutamicum mycothiol S-conjugate amidase.

Authors:  Meiru Si; Mingxiu Long; Muhammad Tausif Chaudhry; Yixiang Xu; Pan Zhang; Lei Zhang; Xihui Shen
Journal:  PLoS One       Date:  2014-12-16       Impact factor: 3.240

Review 10.  The Oxepane Motif in Marine Drugs.

Authors:  Héctor Barbero; Carlos Díez-Poza; Asunción Barbero
Journal:  Mar Drugs       Date:  2017-11-15       Impact factor: 5.118
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