| Literature DB >> 12161147 |
Yuan Cheng1, Fengqi Zhang, Thomas A Rano, Zhijian Lu, William A Schleif, Lori Gabryelski, David B Olsen, Mark Stahlhut, Carrie A Rutkowski, Jiunn H Lin, Lixia Jin, Emilio A Emini, Kevin T Chapman, James R Tata.
Abstract
Indinavir analogues with blocked metabolism sites show highly improved pharmacokinetic profiles in animals. The cis-aminochromanol substituted analogues exhibited excellent potency against both the wild-type (NL4-3) virus and protease inhibitor-resistant HIV strains.Entities:
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Year: 2002 PMID： 12161147 DOI： 10.1016/s0960-894x(02)00424-9
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823