Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines.

Literature DB >> 12161135

Novel inhibitors of plasminogen activator inhibitor-1: development of new templates from diketopiperazines.

Shouming Wang¹, Julian Golec, Warren Miller, Sandra Milutinovic, Adrian Folkes, Susannah Williams, Teresa Brooks, Kevin Hardman, Peter Charlton, Stephen Wren, John Spencer.

Abstract

Several isoquinoline-based templates were identified from the studies of the conformational effects of the diketopiperazine structures for PAI-1 inhibition. Moderate to good activity was retained with the elimination of unattractive characteristics in the diketopiperazine template.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2002 PMID： 12161135 DOI： 10.1016/s0960-894x(02)00389-x

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

2 in total

1. Traceless synthesis of diketopiperazine fused tetrahydro-β-carbolines on soluble polymer support.

Authors: Kaushik Chanda; Cheng-Ting Chou; Jin-Ji Lai; Shu-Fen Lin; Gorakh S Yellol; Chung-Ming Sun
Journal: Mol Divers Date: 2010-10-10 Impact factor: 2.943

2. The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure.

Authors: Francesco Airaghi; Andrea Fiorati; Giordano Lesma; Manuele Musolino; Alessandro Sacchetti; Alessandra Silvani
Journal: Beilstein J Org Chem Date: 2013-01-22 Impact factor: 2.883

2 in total