| Literature DB >> 12161125 |
Zhen-Dan Shi1, Bing-Hui Yang, Yu-Lin Wu, Ya-Juan Pan, Yong-Yong Ji, Ming Yeh.
Abstract
Described herein is the synthesis of a hapten of biocyclo[2,2,2]octene 5 designed to mimic the exo transition-state of an aza Diels-Alder reaction. Immunization of rabbits with this hapten provided polyclonal antibodies, Aza-BSA-3, which were used to synthesize adduct 4b in the first reported antibody-catalyzed exo Diels-Alder reaction.Entities:
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Year: 2002 PMID： 12161125 DOI： 10.1016/s0960-894x(02)00402-x
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823