| Literature DB >> 12161124 |
Shinji Aki1, Takafumi Fujioka, Masashi Ishigami, Jun-ichi Minamikawa.
Abstract
The synthesis of 3,4-diethoxybenzthioamide, the key intermediate for OPC-6535, is achieved by employing Friedel-Crafts reaction of 1,2-diethoxybenzene with potassium thiocyanate in methanesulfonic acid at ambient temperature.Entities:
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Year: 2002 PMID： 12161124 DOI： 10.1016/s0960-894x(02)00398-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823