| Literature DB >> 12161036 |
C L A Mann1, M B Davies, V L Stevenson, S M Leary, M D Boggild, C Ko Ko, P W Jones, A A Fryer, R C Strange, A J Thompson, C P Hawkins.
Abstract
We studied the association between clinical outcome in MS and allelic variants single nucleotide polymorphisms (SNPs) of interleukin-1alpha (IL-1alpha), IL-1beta and a variable number tandem repeat (VNTR) in IL-1 receptor antagonist (IL-1RN). A total of 377 patients with MS were studied. Significant associations between IL-1 genotypes and clinical outcome were found using logistic regression after correction for gender, onset age and disease duration. The same trends were subsequently demonstrated in a second independent group of 67 primary progressive patients. Our results suggest that genetically determined immunomodulation mediated by IL-1 influences long-term prognosis in multiple sclerosis (MS).Entities:
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Year: 2002 PMID： 12161036 DOI： 10.1016/s0165-5728(02)00181-9
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478