Literature DB >> 12161019

ATP induces leukemia inhibitory factor mRNA in cultured rat astrocytes.

Hisashi Yamakuni1, Nami Kawaguchi, Yoshikazu Ohtani, Junji Nakamura, Takahiro Katayama, Takayuki Nakagawa, Masabumi Minami, Masamichi Satoh.   

Abstract

Leukemia inhibitory factor (LIF) is a cytokine involved in the survival and differentiation of the neural cells in the central and peripheral nervous systems. In the present study, we examined the effects of various neurotransmitter receptor agonists on LIF mRNA expression in cultured rat astrocytes, microglia and neurons to elucidate the cell types producing LIF and to clarify the neurotransmitter(s) regulating the mRNA expression. The results demonstrated that the expression of LIF mRNA was intensely induced by ATP in the cultured astrocytes. Experiments using ATP, UTP and related compounds showed the involvement of P2Y2 and P2Y4 purinoceptors in the expression induced by ATP.

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Year:  2002        PMID： 12161019     DOI： 10.1016/s0165-5728(02)00179-0

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  9 in total

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Authors:  Jonathan E Cohen; R Douglas Fields
Journal:  Neuron Glia Biol       Date:  2008-02

Review 7.  Oligodendroglia and neurotrophic factors in neurodegeneration.

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8.  In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain.

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9.  Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity.

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Journal:  J Neuroinflammation       Date:  2012-08-16       Impact factor: 8.322
  9 in total

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