| Literature DB >> 12153462 |
C-P Shen1, K K Wu, L P Shearman, R Camacho, M R Tota, T M Fong, L H T Van der Ploeg.
Abstract
We measured plasma concentrations of agouti-related protein (AGRP) in humans and rats and determined whether these were affected by ingestion of a meal after fasting. In 17 healthy human subjects, the mean plasma concentration of AGRP was lower in the fed state than in the fasted state. Two hours after a breakfast meal, AGRP levels dropped by 39%. By contrast, a continued fast for 2 h increased the average AGRP concentration by 73%. In rats with diet-induced obesity, refeeding resulted in a 50% decrease in plasma AGRP concentrations following a fasting-refeeding protocol. Our results support the notion that plasma AGRP may serve as a biomarker for the transition from a fasted to the satiated state.Entities:
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Year: 2002 PMID： 12153462 DOI： 10.1046/j.1365-2826.2002.00825.x
Source DB: PubMed Journal: J Neuroendocrinol ISSN： 0953-8194 Impact factor: 3.627