| Literature DB >> 12153275 |
Graham B Jones1, Justin M Wright, George Hynd, Justin K Wyatt, Philip M Warner, Robert S Huber, Aiwen Li, Michael W Kilgore, Robert P Sticca, Richard S Pollenz.
Abstract
Efficient routes to three classes of 10-membered oxa-enediynes are presented. The electronic and stereoelectronic contributions to half-lives are supported by density functional theory calculations. One member of this class cyclizes to give an isochroman which binds to and degrades the aryl hydrocarbon receptor (AhR).Entities:
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Year: 2002 PMID： 12153275 DOI： 10.1021/jo0256888
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354