Literature DB >> 12153191

Microwave-assisted solid-phase synthesis of 5-carboxamido-N-acetyltryptamine derivatives.

Adriana Fînaru1, Aurélie Berthault, Thierry Besson, Gérald Guillaumet, Sabine Berteina-Raboin.   

Abstract

[reaction: see text] The synthesis of the indole skeleton of new melatoninergic analogues was realized using solid-phase methodology in association with microwave irradiation. This combination speeds up the solid-phase drug discovery process in rigorously established conditions.

Entities:  

Year:  2002        PMID： 12153191     DOI： 10.1021/ol0259185

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.

Authors:  Paolo Grieco; Minying Cai; Lu Liu; Alexander Mayorov; Kevin Chandler; Dev Trivedi; Guangxin Lin; Pietro Campiglia; Ettore Novellino; Victor J Hruby
Journal:  J Med Chem       Date:  2008-04-15       Impact factor: 7.446

2.  Microwave-assisted Pd(0)-catalyzed amination of aryl halides on solid support.

Authors:  Klaus Weigand; Sylvie Pelka
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

3.  Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.

Authors:  Vassilios Bavetsias; Amir Faisal; Simon Crumpler; Nathan Brown; Magda Kosmopoulou; Amar Joshi; Butrus Atrash; Yolanda Pérez-Fuertes; Jessica A Schmitt; Katherine J Boxall; Rosemary Burke; Chongbo Sun; Sian Avery; Katherine Bush; Alan Henley; Florence I Raynaud; Paul Workman; Richard Bayliss; Spiros Linardopoulos; Julian Blagg
Journal:  J Med Chem       Date:  2013-11-06       Impact factor: 7.446
  3 in total

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