| Literature DB >> 12151960 |
George S Stoica1, Harly E Greenberg, Leonard J Rossoff.
Abstract
Fludarabine monophosphate is a purine nucleoside antimetabolite with efficacy in the treatment of lymphoproliferative disorders and chronic lymphocytic leukemia. It is the 2-fluoro, 5' phosphate derivative of 9-beta-D-arabinofuranosyl adenine (ara-A, vidarabine) and the mechanism of action is through inhibition of DNA synthesis and the cytolytic effects through the induction of endonuclease-independent apoptosis.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12151960 DOI： 10.1097/00000421-200208000-00003
Source DB: PubMed Journal: Am J Clin Oncol ISSN： 0277-3732 Impact factor: 2.339