Genetics of familial idiopathic scoliosis.

The etiology of familial idiopathic scoliosis is unknown. The role of genetic factors in the development of this disorder has been well documented; however, reports of the specific mode of genetic inheritance are inconclusive. These facts, combined with the phenotypic variability of this disorder suggest that the genetic expression of idiopathic scoliosis may be dependent on multiple factors and genetic interactions. Strategies to resolve the complex nature of this condition include genome-wide scanning of an extended family or, alternatively, a well-characterized population of families affected with idiopathic scoliosis.