| Literature DB >> 12151764 |
Mitchell K P Lai1, Shirley W Y Tsang, Paul T Francis, Janet Keene, Tony Hope, Margaret M Esiri, Ian Spence, Christopher P L-H Chen.
Abstract
Serotonin1A receptor density and serotonin concentration were measured in the postmortem neocortex of 17 AD patients who had been prospectively assessed every four months with the Mini-Mental State Examination (MMSE) for a mean of 2.6 years till death. In the frontal cortex, serotonin levels correlated negatively with the annual rate of MMSE decline, while serotonin1A receptor density was positively correlated with the rate of MMSE decline. Our study suggests that reduced serotonin levels and increased serotonin1A receptor density are markers for accelerated cognitive decline in AD, and provides support for the use of serotonin1A antagonists in the treatment of AD.Entities:
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Year: 2002 PMID： 12151764 DOI： 10.1097/00001756-200207020-00021
Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837