Literature DB >> 12151215

TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?

Eitan Winter1, Chris P Ponting.   

Abstract

A family of membrane-associated proteins related to yeast Lag1p and mammalian TRAM has been identified. The family includes the protein product of CLN8, a gene mutated in progressive epilepsy with mental retardation. Mouse CLN8 is also mutated in the mnd/mnd mouse, a model for neuronal ceroid lipofuscinoses. The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum.

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Year:  2002        PMID： 12151215     DOI： 10.1016/s0968-0004(02)02154-0

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  48 in total

1.  Acyl chain specificity of ceramide synthases is determined within a region of 150 residues in the Tram-Lag-CLN8 (TLC) domain.

Authors:  Rotem Tidhar; Shifra Ben-Dor; Elaine Wang; Samuel Kelly; Alfred H Merrill; Anthony H Futerman
Journal:  J Biol Chem       Date:  2011-12-05       Impact factor: 5.157

2.  Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2.

Authors:  Mario Ruiz; Rakesh Bodhicharla; Emma Svensk; Ranjan Devkota; Kiran Busayavalasa; Henrik Palmgren; Marcus Ståhlman; Jan Boren; Marc Pilon
Journal:  Elife       Date:  2018-12-04       Impact factor: 8.140

Review 3.  Correlations between genotype, ultrastructural morphology and clinical phenotype in the neuronal ceroid lipofuscinoses.

Authors:  Sara E Mole; Ruth E Williams; Hans H Goebel
Journal:  Neurogenetics       Date:  2005-09-28       Impact factor: 2.660

4.  Identification of residues critical for topology inversion of the transmembrane protein TM4SF20 through regulated alternative translocation.

Authors:  Jingcheng Wang; Lisa N Kinch; Bray Denard; Ching-En Lee; Elina Esmaeilzadeh Gharehdaghi; Nick Grishin; Jin Ye
Journal:  J Biol Chem       Date:  2019-02-26       Impact factor: 5.157

5.  Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus.

Authors:  Adam Monier; António Pagarete; Colomban de Vargas; Michael J Allen; Betsy Read; Jean-Michel Claverie; Hiroyuki Ogata
Journal:  Genome Res       Date:  2009-05-18       Impact factor: 9.043

6.  Inverting the Topology of a Transmembrane Protein by Regulating the Translocation of the First Transmembrane Helix.

Authors:  Qiuyue Chen; Bray Denard; Ching-En Lee; Sungwon Han; James S Ye; Jin Ye
Journal:  Mol Cell       Date:  2016-08-04       Impact factor: 17.970

Review 7.  Ceramide synthases at the centre of sphingolipid metabolism and biology.

Authors:  Thomas D Mullen; Yusuf A Hannun; Lina M Obeid
Journal:  Biochem J       Date:  2012-02-01       Impact factor: 3.857

8.  Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila.

Authors:  Reinhard Bauer; André Voelzmann; Bernadette Breiden; Ute Schepers; Hany Farwanah; Ines Hahn; Franka Eckardt; Konrad Sandhoff; Michael Hoch
Journal:  EMBO J       Date:  2009-10-15       Impact factor: 11.598

9.  PROS-1/Prospero Is a Major Regulator of the Glia-Specific Secretome Controlling Sensory-Neuron Shape and Function in C. elegans.

Authors:  Sean W Wallace; Aakanksha Singhvi; Yupu Liang; Yun Lu; Shai Shaham
Journal:  Cell Rep       Date:  2016-04-07       Impact factor: 9.423

10.  Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins.

Authors:  Annina Lyly; Carina von Schantz; Claudia Heine; Mia-Lisa Schmiedt; Tessa Sipilä; Anu Jalanko; Aija Kyttälä
Journal:  BMC Cell Biol       Date:  2009-11-26
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