Literature DB >> 12150900

Smad about E2F. TGFbeta repressionof c-Myc via a Smad3/E2F/p107 complex.

Timothy F Kowalik1.   

Abstract

Signaling by TGFbeta regulates the expression of hundreds of genes. The rapid repression of c-Myc stands out because of its roles in growth control and cancer. Recent work shows that c-Myc repression by TGFbeta is mediated by the nuclear translocation of a novel, preformed complex composed of Smad3, E2F4 or E2F5, and the Rb-related factor p107.

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Year:  2002        PMID： 12150900     DOI： 10.1016/s1097-2765(02)00584-1

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  5 in total

1.  Transforming growth factor β suppresses peroxisome proliferator-activated receptor γ expression via both SMAD binding and novel TGF-β inhibitory elements.

Authors:  Sowmya P Lakshmi; Aravind T Reddy; Raju C Reddy
Journal:  Biochem J       Date:  2017-04-24       Impact factor: 3.857

2.  Analysis of genetic aberrations on chromosomal region 8q21-24 identifies E2F5 as an oncogene with copy number gain in prostate cancer.

Authors:  Jin Zhao; Xin-Yang Wu; Xiao-Hui Ling; Zhuo-Yuan Lin; Xin Fu; Ye-Han Deng; Hui-Chan He; Weide Zhong
Journal:  Med Oncol       Date:  2013-02-03       Impact factor: 3.064

3.  Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides.

Authors:  Amer Ahmed Rana; Clara Collart; Michael J Gilchrist; J C Smith
Journal:  PLoS Genet       Date:  2006-10-04       Impact factor: 5.917

4.  Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest.

Authors:  Sharon Sheahan; Christopher O Bellamy; Donald R Dunbar; David J Harrison; Sandrine Prost
Journal:  BMC Cancer       Date:  2007-11-19       Impact factor: 4.430

5.  TGFbeta1 signaling via alphaVbeta6 integrin.

Authors:  Martin P Kracklauer; Christian Schmidt; Guido M Sclabas
Journal:  Mol Cancer       Date:  2003-08-07       Impact factor: 27.401
  5 in total

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