| Literature DB >> 12150870 |
Weidong He1, Miroslav Cik, Luc Van Puyvelde, Jacky Van Dun, Giovanni Appendino, Anne Lesage, Ilse Van der Lindin, Josée E Leysen, Walter Wouters, Simon G Mathenge, Francis P Mudida, Norbert De Kimpe.
Abstract
Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.Entities:
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Year: 2002 PMID： 12150870 DOI： 10.1016/s0968-0896(02)00163-3
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641