Literature DB >> 12150205

Modulation by substrates of the protective effect of cyclosporin A on mitochondrial damage.

Edmundo Chávez1, Cecilia Zazueta, Francisco Correa, Noemí García, César Avilés, Sandra G Robles, César D Rodríguez.   

Abstract

The influence of substrates on the role of cyclosporin A, to promote the closure of the permeability transition pore, was studied. It was found that in succinate-oxidizing mitochondria, cyclosporin inhibited pore opening as induced by carboxyatractyloside. The opposite occurred when mitochondrial respiration was supported by malate-glutamate, i.e., cyclosporin A was unable to block pore opening promoted by carboxyatractyloside. We propose that the failure of cyclosporin A to induce pore closure could be due to a low NADH matrix content.

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Year:  2002        PMID： 12150205     DOI： 10.1016/s0024-3205(02)01486-8

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  3 in total

1.  Blood lymphocyte blastogenesis in patients with thyroid dysfunction: ex vivo response to mitogen activation and cyclosporin A.

Authors:  Garyphallia Papaioannou; Fotios V Michelis; Konstantinos Papamichael; Helen Karga; Ekaterini Tiligada
Journal:  Inflamm Res       Date:  2010-10-24       Impact factor: 4.575

2.  The composition of the incubation medium influences the sensitivity of mitochondrial permeability transition to cyclosporin A.

Authors:  Edmundo Chávez; Noemi García; Cecilia Zazueta; Francisco Correa; César Avilés; Gerardo García; Eros O Balam
Journal:  J Bioenerg Biomembr       Date:  2003-04       Impact factor: 2.945

3.  Regulation of the mitochondrial permeability transition in kidney proximal tubules and its alteration during hypoxia-reoxygenation.

Authors:  Thorsten Feldkamp; Jeong Soon Park; Ratna Pasupulati; Daniela Amora; Nancy F Roeser; M A Venkatachalam; Joel M Weinberg
Journal:  Am J Physiol Renal Physiol       Date:  2009-09-09
  3 in total

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