Literature DB >> 12149007

The reaction of nitric oxide with glutathionylcobalamin.

Donghong Zheng1, Ronald L Birke.   

Abstract

UV-vis stopped-flow results show that glutathionylcobalamin can react with nitric oxide at pH 7 to form nitrosylcob(II)alamin in a reaction second-order overall. From kinetic studies we suggest that nitric oxide attacks glutathionylcobalamin to form a caged transition state followed by formation of the nitrosylcob(II)alamin.

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Year:  2002        PMID： 12149007     DOI： 10.1021/ja017684a

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  7 in total

1.  Mechanistic Studies on the Reaction of Nitrocobalamin with Glutathione: Kinetic evidence for formation of an aquacobalamin intermediate.

Authors:  David T Walker; Rohan S Dassanayake; Kamille A Garcia; Riya Mukherjee; Nicola E Brasch
Journal:  Eur J Inorg Chem       Date:  2013-06-01       Impact factor: 2.524

2.  The X-ray crystal structure of glutathionylcobalamin revealed.

Authors:  Luciana Hannibal; Clyde A Smith; Donald W Jacobsen
Journal:  Inorg Chem       Date:  2010-11-01       Impact factor: 5.165

3.  A simple, convenient method to synthesize cobalamins: synthesis of homocysteinylcobalamin, N-acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, sulfitocobalamin and nitrocobalamin.

Authors:  Edward Suarez-Moreira; Luciana Hannibal; Clyde A Smith; Roberto A Chavez; Donald W Jacobsen; Nicola E Brasch
Journal:  Dalton Trans       Date:  2006-09-21       Impact factor: 4.390

4.  NMR spectroscopy and molecular modelling studies of nitrosylcobalamin: further evidence that the deprotonated, base-off form is important for nitrosylcobalamin in solution.

Authors:  Hanaa A Hassanin; Luciana Hannibal; Donald W Jacobsen; Kenneth L Brown; Helder M Marques; Nicola E Brasch
Journal:  Dalton Trans       Date:  2008-12-05       Impact factor: 4.390

5.  Biphasic modulation of NOS expression, protein and nitrite products by hydroxocobalamin underlies its protective effect in endotoxemic shock: downstream regulation of COX-2, IL-1β, TNF-α, IL-6, and HMGB1 expression.

Authors:  André L F Sampaio; Jesmond Dalli; Vincenzo Brancaleone; Fulvio D'Acquisto; Mauro Perretti; Carmen Wheatley
Journal:  Mediators Inflamm       Date:  2013-05-28       Impact factor: 4.711

6.  The return of the Scarlet Pimpernel: cobalamin in inflammation II - cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS.

Authors:  Carmen Wheatley
Journal:  J Nutr Environ Med       Date:  2007-09

7.  Cobalamin in inflammation III - glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone? How cobalamin may directly regulate the nitric oxide synthases.

Authors:  Carmen Wheatley
Journal:  J Nutr Environ Med       Date:  2008-01-10
  7 in total

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