OBJECTIVE: Researchers have suggested an inverse association between breast-feeding and risk of childhood cancer. We investigated the association between breast-feeding and neuroblastoma in a large case-control study in the United States and Canada. METHODS: Maternal reports of breast-feeding were compared among 393 children six months or older who had neuroblastoma and were identified through the Children's Cancer Group and the Pediatric Oncology Group and 376 age-matched controls identified by random-digit telephone dialing in a telephone interview case-control study. RESULTS: Children with neuroblastoma were less likely to have breast-fed than control children (odds ratio (OR) = 0.6; 95% confidence interval (CI) = 0.5-0.9). The association between breast-feeding and neuroblastoma increased with breast-feeding duration (0-3 months OR = 0.7, CI = 0.4-1.0; 13+ months OR = 0.5, CI = 0.3-0.9). CONCLUSION: Breast-feeding was inversely associated with neuroblastoma and should be encouraged among healthy mothers. Additional research on possible mechanisms of this association may be warranted.
OBJECTIVE: Researchers have suggested an inverse association between breast-feeding and risk of childhood cancer. We investigated the association between breast-feeding and neuroblastoma in a large case-control study in the United States and Canada. METHODS: Maternal reports of breast-feeding were compared among 393 children six months or older who had neuroblastoma and were identified through the Children's Cancer Group and the Pediatric Oncology Group and 376 age-matched controls identified by random-digit telephone dialing in a telephone interview case-control study. RESULTS:Children with neuroblastoma were less likely to have breast-fed than control children (odds ratio (OR) = 0.6; 95% confidence interval (CI) = 0.5-0.9). The association between breast-feeding and neuroblastoma increased with breast-feeding duration (0-3 months OR = 0.7, CI = 0.4-1.0; 13+ months OR = 0.5, CI = 0.3-0.9). CONCLUSION: Breast-feeding was inversely associated with neuroblastoma and should be encouraged among healthy mothers. Additional research on possible mechanisms of this association may be warranted.
Authors: Juan A Ortega-García; Josep Ferrís-Tortajada; Alberto M Torres-Cantero; Offie P Soldin; Encarna Pastor Torres; Jose L Fuster-Soler; Blanca Lopez-Ibor; Luis Madero-López Journal: J Paediatr Child Health Date: 2007-11-12 Impact factor: 1.954
Authors: Elizabeth Bluhm; Dawn Elizabeth McNeil; Sven Cnattingius; Gloria Gridley; Laure El Ghormli; Joseph F Fraumeni Journal: Int J Cancer Date: 2008-12-15 Impact factor: 7.396
Authors: Florence Menegaux; Andrew F Olshan; Joseph P Neglia; Brad H Pollock; Melissa L Bondy Journal: Am J Epidemiol Date: 2004-05-01 Impact factor: 4.897