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Literature DB >> 12145193

Role of integrins in regulating epidermal adhesion, growth and differentiation.

Abstract

Mammalian epidermis is renewed throughout life by proliferation of a multipotential stem cell population and terminal differentiation of stem cell progeny. In recent years, extracellular matrix receptors of the integrin family have been identified as important regulators of epidermal homeostasis, influencing the balance between stem cell renewal and differentiation. Integrin expression is altered when the epidermis is damaged or diseased, and there is good evidence that specific integrins can contribute positively or negatively to pathogenesis. In this review I summarize what is known about the expression and function of epidermal integrins, and highlight the challenges for future research.

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Year: 2002 PMID： 12145193 PMCID： PMC126145 DOI： 10.1093/emboj/cdf399

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

75 in total

1. Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia.

Authors: G H Ashton; P Sorelli; J E Mellerio; F M Keane; R A Eady; J A McGrath
Journal: Br J Dermatol Date: 2001-02 Impact factor: 9.302

Review 2. Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion.

Authors: B P Nguyen; M C Ryan; S G Gil; W G Carter
Journal: Curr Opin Cell Biol Date: 2000-10 Impact factor: 8.382

3. The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin.

Authors: L M Schnapp; N Hatch; D M Ramos; I V Klimanskaya; D Sheppard; R Pytela
Journal: J Biol Chem Date: 1995-09-29 Impact factor: 5.157

4. Enrichment for murine keratinocyte stem cells based on cell surface phenotype.

Authors: H Tani; R J Morris; P Kaur
Journal: Proc Natl Acad Sci U S A Date: 2000-09-26 Impact factor: 11.205

5. Beta 8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV, and fibronectin.

Authors: K Venstrom; L Reichardt
Journal: Mol Biol Cell Date: 1995-04 Impact factor: 4.138

Review 6. Integrin cytoplasmic domain-binding proteins.

Authors: S Liu; D A Calderwood; M H Ginsberg
Journal: J Cell Sci Date: 2000-10 Impact factor: 5.285

7. Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination.

Authors: S Raghavan; C Bauer; G Mundschau; Q Li; E Fuchs
Journal: J Cell Biol Date: 2000-09-04 Impact factor: 10.539

8. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells.

Authors: L M Schnapp; J M Breuss; D M Ramos; D Sheppard; R Pytela
Journal: J Cell Sci Date: 1995-02 Impact factor: 5.285

9. Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling.

Authors: J M Breuss; J Gallo; H M DeLisser; I V Klimanskaya; H G Folkesson; J F Pittet; S L Nishimura; K Aldape; D V Landers; W Carpenter
Journal: J Cell Sci Date: 1995-06 Impact factor: 5.285

10. Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.

Authors: G Zambruno; P C Marchisio; A Marconi; C Vaschieri; A Melchiori; A Giannetti; M De Luca
Journal: J Cell Biol Date: 1995-05 Impact factor: 10.539

196 in total

Review 1. Integrin signalling and the cellular response to ionizing radiation.

Authors: Nils Cordes; Viktor Meineke
Journal: J Mol Histol Date: 2004-03 Impact factor: 2.611

2. c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation.

Authors: Anne Wilson; Mark J Murphy; Thordur Oskarsson; Konstantinos Kaloulis; Michael D Bettess; Gabriela M Oser; Anne-Catherine Pasche; Christian Knabenhans; H Robson Macdonald; Andreas Trumpp
Journal: Genes Dev Date: 2004-11-15 Impact factor: 11.361

3. α6β4 integrin, a master regulator of expression of integrins in human keratinocytes.

Authors: Kristina R Kligys; Yvonne Wu; Susan B Hopkinson; Surinder Kaur; Leonidas C Platanias; Jonathan C R Jones
Journal: J Biol Chem Date: 2012-04-06 Impact factor: 5.157

4. Diverse epigenetic strategies interact to control epidermal differentiation.

Authors: Klaas W Mulder; Xin Wang; Carles Escriu; Yoko Ito; Roland F Schwarz; Jesse Gillis; Gábor Sirokmány; Giacomo Donati; Santiago Uribe-Lewis; Paul Pavlidis; Adele Murrell; Florian Markowetz; Fiona M Watt
Journal: Nat Cell Biol Date: 2012-06-24 Impact factor: 28.824

5. Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue.

Authors: Patricia E Burger; Xiaozhong Xiong; Sandra Coetzee; Sarah N Salm; David Moscatelli; Ken Goto; E Lynette Wilson
Journal: Proc Natl Acad Sci U S A Date: 2005-05-17 Impact factor: 11.205

10. Scl1, the multifunctional adhesin of group A Streptococcus, selectively binds cellular fibronectin and laminin, and mediates pathogen internalization by human cells.

Authors: Clayton C Caswell; Heaven Oliver-Kozup; Runlin Han; Ewa Lukomska; Slawomir Lukomski
Journal: FEMS Microbiol Lett Date: 2009-11-23 Impact factor: 2.742