Goodpasture syndrome: pathophysiology, diagnosis, and management.

Goodpasture syndrome is an autoimmune disease characterized by glomerulonephritis, pulmonary hemorrhage, and autoantibodies to the glomerular and alveolar basement membranes. The cause is unknown, and if untreated, Goodpasture syndrome usually is fatal. Early diagnosis and prompt initiation of therapy can decrease disease progression and increase chances of survival. Treatment modalities remain controversial and vary among practitioners.